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SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer
Peroxisomes account for ~35% of total H2O2 generation in mammalian tissues. Peroxisomal ACOX1 (acyl‐CoA oxidase 1) is the first and rate‐limiting enzyme in fatty acid β‐oxidation and a major producerExpand
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Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network
Additional sex combs-like 1 (ASXL1) interacts with BRCA1-associated protein 1 (BAP1) deubiquitinase to oppose the polycomb repressive complex 1 (PRC1)-mediated histone H2A ubiquitylation. GermlineExpand
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Dysregulation of MALAT1 and miR-619-5p as a prognostic indicator in advanced colorectal carcinoma.
The present study aimed to detect the expression of metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and microRNA (miR)-619-5p in colorectal carcinoma (CRC), and to evaluate theExpand
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Dysregulation of MALAT 1 and miR-619-5 p as a prognostic indicator in advanced colorectal carcinoma
The present study aimed to detect the expression of metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and microRNA (miR)-619-5p in colorectal carcinoma (CRC), and to evaluate theExpand
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Values of fecal microRNA-141, -17-3p and -92a-3p in the diagnosis and prognostic evaluation of colorectal cancer
Objective: To explore the values of fecal mircoRNA (miRNA, miR) in diagnosis and prognostic evaluation of colorectal cancer. Methods: Fifty colorectal cancer patients and fifty healthy controls wereExpand
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UHRF1BP1: A tumor suppressor gene associated with bladder cancer risk in Han Chinese
Junlong Wu1, Yao Zhu1, Dingwei Ye1, Meilin Wang3, Jianfeng Xu3, Chengyuan Gu1, Weijie Gu1 1. Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China 2. Department ofExpand
Author Correction: Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade
Somatic cell reprogramming provides insight into basic principles of cell fate determination, which remain poorly understood. Here we show that the transcription factor Glis1 induces multi-levelExpand