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Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular level.
Detecting positive Darwinian selection at the DNA sequence level has been a subject of considerable interest. However, positive selection is difficult to detect because it often operates episodicallyExpand
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Evolution by gene duplication: an update
The importance of gene duplication in supplying raw genetic material to biological evolution has been recognized since the 1930s. Recent genomic sequence data provide substantial evidence for theExpand
  • 1,705
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Rates of Conservative and Radical Nonsynonymous Nucleotide Substitutions in Mammalian Nuclear Genes
  • J. Zhang
  • Medicine, Biology
  • Journal of Molecular Evolution
  • 2000
Abstract. To understand the process and mechanism of protein evolution, it is important to know what types of amino acid substitutions are more likely to be under selection and what types are mostlyExpand
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Rapid Subfunctionalization Accompanied by Prolonged and Substantial Neofunctionalization in Duplicate Gene Evolution
Gene duplication is the primary source of new genes. Duplicate genes that are stably preserved in genomes usually have divergent functions. The general rules governing the functional divergence,Expand
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More genes underwent positive selection in chimpanzee evolution than in human evolution
Observations of numerous dramatic and presumably adaptive phenotypic modifications during human evolution prompt the common belief that more genes have undergone positive Darwinian selection in theExpand
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Impacts of gene essentiality, expression pattern, and gene compactness on the evolutionary rate of mammalian proteins.
Understanding the determinants of the rate of protein sequence evolution is of fundamental importance in evolutionary biology. Many recent studies have focused on the yeast because of theExpand
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The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms
It was first noticed 100 years ago that mutations tend to affect more than one phenotypic characteristic, a phenomenon that was called 'pleiotropy'. Because pleiotropy was found so frequently, theExpand
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Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes.
  • P. Shi, J. Zhang
  • Biology, Medicine
  • Molecular biology and evolution
  • 1 February 2006
Taste reception is fundamental to diet selection in many animals. The genetic basis underlying the evolution and diversity of taste reception, however, is not well understood. Recent discoveries ofExpand
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Comparative genomic analysis identifies an evolutionary shift of vomeronasal receptor gene repertoires in the vertebrate transition from water to land.
Two evolutionarily unrelated superfamilies of G-protein coupled receptors, V1Rs and V2Rs, bind pheromones and "ordinary" odorants to initiate vomeronasal chemical senses in vertebrates, which playExpand
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Balanced Codon Usage Optimizes Eukaryotic Translational Efficiency
Cellular efficiency in protein translation is an important fitness determinant in rapidly growing organisms. It is widely believed that synonymous codons are translated with unequal speeds and thatExpand
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