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Severely suppressed bone turnover: a potential complication of alendronate therapy.
The findings raise the possibility that severe suppression of bone turnover may develop during long-term alendronate therapy, resulting in increased susceptibility to, and delayed healing of, nonspinal fractures, and the need for increased awareness and monitoring. Expand
Blood biomarkers of vitamin D status.
  • J. Zerwekh
  • Biology, Medicine
  • The American journal of clinical nutrition
  • 1 April 2008
This article reviews the currently available methods for serum 25(OH)D quantitation and considers important issues such as whether both the D2 and the D3 forms of the vitamin should be assayed, whether total or free concentrations are most important, and what measures should be taken to ensure the fidelity of the measurements. Expand
The Effects of Twelve Weeks of Bed Rest on Bone Histology, Biochemical Markers of Bone Turnover, and Calcium Homeostasis in Eleven Normal Subjects
The human skeleton appears to respond to unloading by a rapid and sustained increase in bone resorption and a more subtle decrease in bone formation. Expand
Cardiac atrophy after bed rest and spaceflight.
It is suggested that cardiac atrophy is due to a physiological adaptation to reduced myocardial load and work in real or simulated microgravity and demonstrates the plasticity of cardiac muscle under different loading conditions. Expand
Biochemical changes associated with the symptomatic human intervertebral disk.
Significant changes in disk biochemistry are associated with the symptomatic disk, and these changes could contribute to the development of the painful disk syndrome. Expand
Porous ceramics as bone graft substitutes in long bone defects: A biomechanical, histological, and radiographic analysis
Biomechanical testing and radiographic evauation revealed that the addition of bone marrow aspirate was essential for tricalcium phosphate and hydroxyapatite to achieve results comparable with those of cancellous bone, and this degradation took place only after a degree of mechanical competence necessary for weight‐bearing was achieved. Expand
Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D3: point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X
The unique properties of these genetically altered receptors establish a new subclass of natural human VDR mutants that illustrate, in vivo, the importance of both 1,25-(OH)2D3 binding and heterodimerization with RXR in VDR action. Expand
Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.
Data show that 7alpha-hydroxylase and the pathway of bile acid synthesis initiated by this enzyme are essential for proper absorption of dietary lipids and fat-soluble vitamins in newborn mice, but not for the maintenance of serum cholesterol and lipid levels. Expand
The role of dietary sodium on renal excretion and intestinal absorption of calcium and on vitamin D metabolism.
It is concluded that in normal subjects, Na-induced renal hypercalciuria is accompanied by increased 1,25-(OH)2D synthesis and enhanced intestinal Ca absorption and mediation by PTH is suggested. Expand
Unusual mid‐shaft fractures during long‐term bisphosphonate therapy
Bisphosphonates are the most commonly prescribed medications for the treatment of osteoporosis and there is concern that chronic administration of these agents could result in severe suppression of bone turnover with increased risk of nonvertebral fractures. Expand