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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
TLDR
Moderate powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Expand
Central nervous system sarcoidosis--diagnosis and management.
TLDR
The benefit of a large patient database prospectively studied, with extended follow-up, is discussed in order to learn more about prognosis and advance therapy in neurosarcoidosis. Expand
Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial
TLDR
Treatment with cannabinoids did not have a beneficial effect on spasticity when assessed with the Ashworth scale, but objective improvement in mobility and patients' opinion of an improvement in pain suggest cannabinoids might be clinically useful. Expand
Rating scales as outcome measures for clinical trials in neurology: problems, solutions, and recommendations
TLDR
It is shown that improvements in the scientific rigour of rating scales can improve the chances of reaching the correct conclusions about the effectiveness of treatments. Expand
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
TLDR
This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals. Expand
Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up
TLDR
These data provide limited evidence for a longer term treatment effect of cannabinoids in multiple sclerosis, and a long term placebo controlled study is now needed to establish whether cannabinoids may have a role beyond symptom amelioration in MS. Expand
The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS)
TLDR
The findings are suggestive of a clinical effect of cannabis on incontinence episodes in patients with MS, in contrast to the negative finding of the CAMS study, where no difference was seen in the primary outcome of spasticity. Expand
MUltiple Sclerosis and Extract of Cannabis: results of the MUSEC trial
TLDR
The study met its primary objective to demonstrate the superiority of CE over placebo in the treatment of muscle stiffness in MS and was supported by results for secondary efficacy variables. Expand
Review: Glial lineages and myelination in the central nervous system
TLDR
There is growing evidence, especially from studies of glial cell implantation, that oligodendrocyte precursors persist in the adult nervous system and provide a limited capacity for the restoration of structure and function in myelinated pathways damaged by injury or disease. Expand
Glial lineages and myelination in the central nervous system.
TLDR
There is growing evidence, especially from studies of glial cell implantation, that oligodendrocyte precursors persist in the adult nervous system and provide a limited capacity for the restoration of structure and function in myelinated pathways damaged by injury or disease. Expand
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