J. Zajac

Publications162
h-index37
Citations4,587
Highly Influential Citations102
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Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine.
TLDR
In vivo binding studies showed that M6G exerts its antinociceptive effect at low (less than 1%) fractional occupancy of [3H]diprenorphine-specific binding sites, which appears to have greater pharmacological potency than morphine, which in comparison possesses a low intrinsic efficacy.
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Pharmacological characterization of human NPFF(1) and NPFF(2) receptors expressed in CHO cells by using NPY Y(1) receptor antagonists.
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Pre- and postsynaptic distribution of μ, δ and κ opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord
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Functional characterization of a human receptor for neuropeptide FF and related peptides
TLDR
RT – PCR analysis of human tissues mRNA revealed that expression of NPFFR was mainly detected in placenta, thymus and at lower levels in pituitary gland, spleen and testis, demonstrating the involvement of Gi family members.
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Pre- and postsynaptic distribution of mu, delta and kappa opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord.
TLDR
The results are discussed with respect to the contribution of pre- and postsynaptic depressive effects of opiates on the transmission of noxious messages at the level of the dorsal horn.
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Opioid receptor subtypes in the rat spinal cord: electrophysiological studies with μ- and δ-opioid receptor agonists in the control of nociception
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Autoradiographic study of μ and δ opioid binding sites and neutral endopeptidase-24.11 in rat after dorsal root rhizotomy
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GRK2 Protein-mediated Transphosphorylation Contributes to Loss of Function of μ-Opioid Receptors Induced by Neuropeptide FF (NPFF2) Receptors*
TLDR
GPCR kinase 2 (GRK2) contributes to the NPFF-induced phosphorylation and loss of function of MOP receptor and could play a role in heterologous desensitization of GPCRs.
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Neuropeptide FF, pain and analgesia.
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Opioid-modulating peptides: mechanisms of action.
TLDR
Two different mechanisms are clearly involved in the control of opioid functions by opioid-modulating peptides: a circuitry-induced mechanism for nociceptin and dynorphin, and a cellular anti-opioid mechanism for NPFF and CCK.
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