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Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum
Loss- and gain-of-function mutations in the broadly expressed gene Lrp5 affect bone formation, causing osteoporosis and high bone mass, respectively. Although Lrp5 is viewed as a Wnt coreceptor,Expand
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Low testosterone levels are common and associated with insulin resistance in men with diabetes.
CONTEXT Low testosterone levels are common in men with type 2 diabetes and may be associated with insulin resistance. OBJECTIVE We investigated prevalence of testosterone deficiency and theExpand
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Parathyroid hormone-related protein purified from a human lung cancer cell line.
A protein with biological activities similar to parathyroid hormone (PTH) has been purified from serum-free culture medium obtained from a human lung cancer cell line (BEN). A major protein band ofExpand
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Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice
To identify mechanisms of anabolic androgen action in muscle, we generated male and female genomic androgen receptor (AR) knockout (ARKO) mice, and characterized muscle mass, contractile function,Expand
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Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo
Amylin is a member of the calcitonin family of hormones cosecreted with insulin by pancreatic β cells. Cell culture assays suggest that amylin could affect bone formation and bone resorption, thisExpand
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Bone and metabolic health in patients with non-metastatic prostate cancer who are receiving androgen deprivation therapy.
Androgen deprivation therapy (ADT) in men with prostate cancer increases the risk of osteoporotic fractures, type 2 diabetes and, possibly, cardiovascular events. There is considerable uncertaintyExpand
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Genomic actions of the androgen receptor are required for normal male sexual differentiation in a mouse model.
Androgens mediate their effects in target cells via the androgen receptor (AR), which acts predominantly as a ligand-dependent transcription factor. In addition, androgens induce rapid activation ofExpand
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Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial
OBJECTIVE To determine whether testosterone therapy improves glucose metabolism in men with type 2 diabetes (T2D) and lowered testosterone. RESEARCH DESIGN AND METHODS We conducted a randomized,Expand
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Transgenic mice that express Cre recombinase in osteoclasts
To study the physiological control of osteoclasts, the bone resorbing cells, we generated transgenic mice carrying the Cre recombinase gene driven by either the tartrate‐resistant acid phosphataseExpand
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Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice.
Androgens promote anabolism in skeletal muscle; however, effects on subsequent muscle function are less well defined because of a lack of reliable experimental models. We established a rigorous modelExpand
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