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Non-effective dose of exogenously applied l-DOPA itself stereoselectively potentiates postsynaptic D2 receptor-mediated locomotor activities of conscious rats
We attempted to clarify whether or not under inhibition of central dopa decarboxylase non-effective i.p. doses of L-dopa potentiate D2 receptor-mediated locomotor activities without conversion toExpand
Transmitter‐Like Basal and K+‐Evoked Release of 3,4‐Dihydroxyphenylalanine from the Striatum in Conscious Rats Studied by Microdialysis
Abstract: Using microdialysis and HPLC, characteristics of the release of endogenous 3,4‐dihydroxyphenylalanine (DOPA) from striatum in conscious rats were studied in comparison with those ofExpand
Evidence for l-DOPA systems responsible for cardiovascular control in the nucleus tractus solitarii of the rat
Microinjections of L-DOPA (10-100 ng) into the medial area of the nucleus tractus solitarii (NTS) led to dose-dependent decreases in arterial blood pressure and heart rate in rats treated with i.p.Expand
Endogenously released l-DOPA itself tonically functions to potentiate postsynaptic D2 receptor-mediated locomotor activities of conscious rats
A non-effective dose of exogenously applied L-dopa itself stereoselectively potentiates postsynaptic D2 receptor-mediated locomotor activities of rats. We further attempted to clarify whether or notExpand
Transmitter-like 3,4-dihydroxyphenylalanine is tonically released by nicotine in striata of conscious rats.
Microdialysis and high performance liquid chromatography with an electrochemical detector were applied to compare the characteristics of nicotine-evoked release of endogenousExpand
l-DOPA systems for blood pressure regulation in the lower brainstem
We have explored probable neurotransmitter roles of L-3,4-dihydroxyphenylalanine (L-DOPA) in baroreceptor reflex and blood pressure regulation in depressor sites of the nucleus tractus solitariiExpand
Baroreceptor-aortic nerve-mediated release of endogenous L-3,4-dihydroxyphenylalanine and its tonic depressor function in the nucleus tractus solitarii of rats
We have proposed that L-3,4-dihydroxyphenylalanine (L-DOPA) is a neurotransmitter and/or neuromodulator in the central nervous system [Misu Y. and Goshima Y. (1993) Trends pharmac. Sci. 14, 119-123].Expand
Evidence forl-DOPA relevant to modulation of sympathetic activity in the rostral ventrolateral medulla of rats
By microdialysis in the rostral ventrolateral medulla (RVLM) of anesthetized rats, the spontaneous L-3,4-dihydroxyphenylalanine (DOPA) release was partially Ca(2+)-dependent andExpand
Transmitter-like l-3,4-dihydroxyphenylalanine tonically functions to mediate vasodepressor control in the caudal ventrolateral medulla of rats
By microdialysis in the unilateral caudal ventrolateral medulla (CVLM) of anesthetized rats, the spontaneous L-3,4-dihydroxyphenylalanine (L-DOPA) release was in part tetrodotoxin-sensitive orExpand
Endogenously released DOPA is probably relevant to nicotine-induced increases in locomotor activities of rats.
The relevance of endogenously released DOPA to the (+/-)-nicotine-induced increase in locomotor activities was explored in rats. This increase was dose (0.1-1.0 mg/kg, s.c.)-dependent,Expand
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