• Publications
  • Influence
Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain, which is characterized by the formation of extracellular amyloid plaques (or senile plaques) and intracellularExpand
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The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis.
BACKGROUND Neuropsychiatric symptoms (NPS) are being increasingly recognized as common serious problems in Alzheimer's disease (AD). However, published data on the prevalence of NPS in persons withExpand
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Epigenetic mechanisms in Alzheimer's disease: Implications for pathogenesis and therapy
The vast majority of Alzheimer's disease (AD) are late-onset forms (LOAD) likely due to the interplay of environmental influences and individual genetic susceptibility. Epigenetic mechanisms,Expand
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Apolipoprotein E in Alzheimer's disease: an update.
The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been irrefutably recognizedExpand
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Meta-analysis of modifiable risk factors for Alzheimer's disease
  • W. Xu, Lan Tan, +7 authors J. Yu
  • Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
  • 20 August 2015
Background The aetiology of Alzheimer's disease (AD) is believed to involve environmental exposure and genetic susceptibility. The aim of our present systematic review and meta-analysis was toExpand
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Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies: systematic review with
  • H. Wang, J. Yu, +6 authors Lan Tan
  • Psychology, Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
  • 14 May 2014
Objective Recently, several large randomised controlled trials about the treatments of cognitive impairment or dementia due to Parkinson's disease (CIND-PD or PDD) and dementia with Lewy bodies (DLB)Expand
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Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagy
Recent clinical trials report that metformin, an activator of AMP‐activated protein kinase (AMPK) used to treat type 2 diabetes, significantly reduces the risk of stroke by actions that areExpand
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Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease
Triggering receptor expressed on myeloid cells 2 (TREM2) gene is a recently identified susceptibility gene for Alzheimer’s disease (AD), as its low-frequency variants increase the risk of thisExpand
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Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease.
The bridging integrator 1 (BIN1) gene, also known as amphiphysin 2, has recently been identified as the most important risk locus for late onset Alzheimer's disease (LOAD), after apolipoprotein EExpand
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TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice
As a novel risk gene for Alzheimer's disease (AD), triggering receptor expressed on myeloid cells 2 (TREM2) gene encodes a type I transmembrane receptor that is uniquely expressed by the microglia inExpand
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