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A Genomewide Association Study of Citalopram Response in Major Depressive Disorder
TLDR
Although the findings reported here do not meet a genomewide threshold for significance, the regions identified from this study provide targets for independent replication and novel pathways to investigate mechanisms of antidepressant response. Expand
Life extension factor klotho enhances cognition.
TLDR
It is shown that a lifespan-extending variant of the human KLOTHO gene, KL-VS, is associated with enhanced cognition in heterozygous carriers and may enhance cognition and counteract cognitive deficits at different life stages. Expand
Frontotemporal dementia due to C9ORF72 mutations
TLDR
Patients with the C9ORF72 hexanucleotide repeat expansion develop bvFTD, ALS, or FTD-MND with similar clinical and imaging features to sporadic cases, suggesting slower disease progression and thalamic atrophy represents a novel and unexpected feature. Expand
Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion
TLDR
Some bvFTD-SP patients may have neurodegenerative pathology, and C9ORF72 mutations should be considered in patients with bv FTD- SP and a family history of dementia or motor neuron disease. Expand
Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion.
TLDR
It is suggested that patients with behavioural variant frontotemporal dementia with or without the C9orf72 expansion show convergent large-scale network breakdowns despite distinctive atrophy patterns and task-free functional magnetic resonance imaging shows promise in detecting early-stage disease in C 9orf72 carriers. Expand
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
TLDR
The genetic results suggest that for a subset of patients, immune dysfunction may contribute to FTD risk, and have potential implications for clinical trials targeting immune dysfunction in patients with FTD. Expand
The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease
TLDR
The findings suggest that microglial genes show enriched expression in AD-vulnerable brain regions, are up regulated during aging and neurodegeneration in mice, and are upregulated in pathologically affected brain regions in AD. Expand
Novel loci for major depression identified by genome-wide association study of STAR*D and meta-analysis of three studies
TLDR
A genome-wide association study of major depressive disorder (MDD) in 1221 cases from the Sequenced Treatment Alternatives to Relieve Depression study and 1636 screened controls, and a meta-analysis of three European-ancestry MDD GWAS data sets, which considers GRM7 a strong MDD candidate gene. Expand
Heightened emotional contagion in mild cognitive impairment and Alzheimer’s disease is associated with temporal lobe degeneration
TLDR
It is suggested that in MCI and AD, neurodegeneration of temporal lobe structures important for affective signal detection and emotion inhibition are associated with up-regulation of emotion-generating mechanisms. Expand
Variation in longevity gene KLOTHO is associated with greater cortical volumes
TLDR
This work investigated whether carrying one copy of the protective haplotype “KL‐VS” in longevity gene KLOTHO (KL) is associated with greater gray matter volume in healthy human aging compared to carrying no copies. Expand
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