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A Genomewide Association Study of Citalopram Response in Major Depressive Disorder
Life extension factor klotho enhances cognition.
Frontotemporal dementia due to C9ORF72 mutations
Patients with the C9ORF72 hexanucleotide repeat expansion develop bvFTD, ALS, or FTD-MND with similar clinical and imaging features to sporadic cases, suggesting slower disease progression and thalamic atrophy represents a novel and unexpected feature.
Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion.
- Suzee E Lee, Anna M. Khazenzon, W. Seeley
- Psychology, BiologyBrain : a journal of neurology
- 1 November 2014
It is suggested that patients with behavioural variant frontotemporal dementia with or without the C9orf72 expansion show convergent large-scale network breakdowns despite distinctive atrophy patterns and task-free functional magnetic resonance imaging shows promise in detecting early-stage disease in C 9orf72 carriers.
Heightened emotional contagion in mild cognitive impairment and Alzheimer’s disease is associated with temporal lobe degeneration
- V. Sturm, J. Yokoyama, W. Seeley, J. Kramer, B. Miller, K. Rankin
- PsychologyProceedings of the National Academy of Sciences
- 28 May 2013
It is suggested that in MCI and AD, neurodegeneration of temporal lobe structures important for affective signal detection and emotion inhibition are associated with up-regulation of emotion-generating mechanisms.
Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion
- Baber K. Khan, J. Yokoyama, B. Miller
- Medicine, PsychologyJournal of Neurology, Neurosurgery & Psychiatry
- 7 March 2012
Some bvFTD-SP patients may have neurodegenerative pathology, and C9ORF72 mutations should be considered in patients with bv FTD- SP and a family history of dementia or motor neuron disease.
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
The genetic results suggest that for a subset of patients, immune dysfunction may contribute to FTD risk, and have potential implications for clinical trials targeting immune dysfunction in patients with FTD.
Polygenic hazard score: an enrichment marker for Alzheimer’s associated amyloid and tau deposition
The results show that even after accounting for APOE ε4 effects, PHS may be useful in MCI and preclinical AD therapeutic trials to enrich for biomarker-positive individuals at highest risk for short-term clinical progression.
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
A PHS for quantifying individual differences in age-specific genetic risk for Alzheimer’s Disease is developed and may prove useful for stratifying AD risk and as an enrichment strategy in therapeutic trials.
Variation in longevity gene KLOTHO is associated with greater cortical volumes
- J. Yokoyama, V. Sturm, D. Dubal
- Biology, PsychologyAnnals of clinical and translational neurology
- 26 January 2015
This work investigated whether carrying one copy of the protective haplotype “KL‐VS” in longevity gene KLOTHO (KL) is associated with greater gray matter volume in healthy human aging compared to carrying no copies.