• Publications
  • Influence
Two Epstein–Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma
Epstein–Barr virus (EBV) contributes to the development of several human cancers including the endemic form of Burkitt's lymphoma (BL). In culture, EBV induces the continuous proliferation of primaryExpand
  • 178
  • 16
Complete worldwide operative experience in laparoscopic diaphragm pacing: results and differences in spinal cord injured patients and amyotrophic lateral sclerosis patients
BackgroundDiaphragm movement is essential for adequate ventilation, and when the diaphragm is adversely affected patients face lifelong positive-pressure mechanical ventilation or death. This reportExpand
  • 154
  • 13
CYP1A1 genetic polymorphisms and in situ colorectal cancer.
Numerous studies have associated colorectal adenoma with smoking and large bowel cancer with consumption of foods potentially containing polycyclic aromatic hydrocarbons. Enhanced metabolicExpand
  • 157
  • 9
Protein profiles associated with survival in lung adenocarcinoma
  • G. Chen, Tarek G Gharib, +14 authors D. Beer
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 22 October 2003
Morphologic assessment of lung tumors is informative but insufficient to adequately predict patient outcome. We previously identified transcriptional profiles that predict patient survival, and hereExpand
  • 247
  • 6
  • PDF
Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors
BackgroundAdenocarcinomas of the tongue are rare and represent the minority (20 to 25%) of salivary gland tumors affecting the tongue. We investigated the utility of massively parallel sequencing toExpand
  • 172
  • 6
Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis.
PURPOSE The purpose of this study was to determine whether expression of migration inhibitory factor (MIF) is increased in non-small cell lung cancer, and whether it correlates with angiogenesisExpand
  • 139
  • 5
Patient-Derived First Generation Xenografts of Non–Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy
Purpose: Current chemotherapeutic regimens have only modest benefit for non–small cell lung cancer (NSCLC) patients. Cumulative toxicities/drug resistance limit chemotherapy given after theExpand
  • 161
  • 5
  • PDF
Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma
William Lockwood and colleagues show that the focal amplification of a gene, BRF2, on Chromosome 8p12 plays a key role in squamous cell carcinoma of the lung.
  • 86
  • 5
  • PDF
Empyema: an increasing concern in Canada.
BACKGROUND Empyema is a suppurative infection of the pleural space. Without prompt treatment, it can result in significant hospital stays, more invasive treatments as it progresses, and substantialExpand
  • 118
  • 4
  • PDF
Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas
The C-CRK gene, cellular homolog of the avian v-crk oncogene, encodes two alternatively spliced adaptor signaling proteins, CRKI (28 kDa) and CRKII (40 kDa). Both CRKI and CRKII have been shown toExpand
  • 81
  • 4