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Signalling mechanisms in sphingosine 1‐phosphate‐promoted mesangial cell proliferation
This work has shown that S1P acts not only as an extracellular mediator but also as an intracellular second messenger, resulting in the proliferation of various different types of cells, including mesangial cells.
Antitumor Activity of Small Interfering RNA/Cationic Liposome Complex in Mouse Models of Cancer
By combining siRNA with the authors' cationic liposome, the difficulty of administering siRNA to animals in ways that can be applied in human therapy is overcame, expected to provide a novel siRNA therapy for cancer patients.
Therapeutic effects of microRNA-582-5p and -3p on the inhibition of bladder cancer progression.
It is shown that miRNA (miR)-582-5p and -3p, which are strongly decreased in high-grade bladder cancer clinical samples, regulate tumor progression in vitro and in vivo, and are a potential therapeutic target in the treatment of invasive bladder cancer.
A new RNA synthetic method with a 2'-O-(2-cyanoethoxymethyl) protecting group.
A novel method for the synthesis of RNA oligomers with 2-cyanoethoxymethyl (CEM) as the 2'-hydroxyl protecting group has been developed. The new method allows the synthesis of oligoribonucleotides
Tumor regression in mice by delivery of Bcl-2 small interfering RNA with pegylated cationic liposomes.
A siRNA that is sequence specific for the antiapoptotic bcl-2 mRNA complexed with a pegylated liposome incorporating a C-18 lipid (PEG-LIC) by i.v. administration showed no side effects on repeated administration and the strength of its antitumor activity may be attributed to its high uptake by the tumors.
Metabolism of 75Se-selenite by human whole blood in vitro.
75Se released from cells is bound by a plasma protein but can be removed from the protein by treatment with cysteine, and studies suggest that the released selenium is in an altered form or state, although this product has not been characterized.
Nonionic nucleic acid analogues. Synthesis and characterization of dideoxyribonucleoside methylphosphonates.
Since these nonionic oligonucleotide analogues are taken up by cells in culture, they show promise as molecular probes for the function and structure of nucleic acids inside living cells.
Chemical synthesis of a very long oligoribonucleotide with 2-cyanoethoxymethyl (CEM) as the 2′-O-protecting group: structural identification and biological activity of a synthetic 110mer
The identity of the 110mer was confirmed by both physicochemical and biological methods, and it showed sense-selective specific gene-silencing activity and is the longest chemically synthesized RNA oligomer reported to date.
Targeted Induction of Interferon-λ in Humanized Chimeric Mouse Liver Abrogates Hepatotropic Virus Infection
Chimeric mice harboring humanized livers demonstrate that IFN-λs play an important role in the defense against human hepatic virus infection.
Global analysis of differentially expressed genes during progression of calcium oxalate nephrolithiasis.
A cDNA microarray study from a rat kidney normalized cDNA library is constructed, and the pattern of gene expression in rat kidneys from a calcium oxalate (CaOx) nephrolithiasis model is investigated.