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Adherent dendritic cells expressing high levels of interleukin‐10 and low levels of interleukin‐12 induce antigen‐specific tolerance to experimental autoimmune encephalomyelitis
- J. Yang, L. Xu, Y. Huang, P. H. van der Meide, H. Link, B. Xiao
- Biology, Medicine
- 1 November 2000
We have previously shown that tolerance can be induced against acute experimental autoimmune encephalomyelitis (EAE) in Lewis rats by bone marrow‐derived dendritic cells (DC) that have been pulsed in… Expand
Suppression of ongoing experimental allergic encephalomyelitis (EAE)in Lewis rats: synergistic effects of myelin basic protein (MBP) peptide68–86 and IL‐4
- L. Xu, Y. Huang, J. Yang, P. H. van der Meide, H. Link, B. Xiao
- Clinical and experimental immunology
- 1 June 2000
Mucosal myelin autoantigen administration effectively prevented EAE, but mostly failed to treat ongoing EAE. Patients with multiple sclerosis (MS), for which EAE is considered an animal model, did… Expand
Limitation of nitric oxide production: cells from lymph node and spleen exhibit distinct difference in nitric oxide production.
Many types of cells in the immune system have been found to produce nitric oxide (NO), which performs multiplex functions. However, in myelin basic protein peptide 68-86 (MBP 68-86)-induced… Expand