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Topographic diversity of fungal and bacterial communities in human skin
Traditional culture-based methods have incompletely defined the microbial landscape of common recalcitrant human fungal skin diseases, including athlete’s foot and toenail infections. Skin protects… Expand
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p
The bromodomain is an ∼110 amino acid module found in histone acetyltransferases and the ATPase component of certain nucleosome remodelling complexes. We report the crystal structure at 1.9 Å… Expand
LncRNA-Dependent Mechanisms of Androgen Receptor-regulated Gene Activation Programs
Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis, their potential involvement in regulated… Expand
An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells
- Xu-Bao Shi, L. Xue, +7 authors R. D. deVere White
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 11 December 2007
Although prostate cancer (CaP) is the most frequently diagnosed malignant tumor and the second leading cause of cancer deaths in American men, the mechanisms explaining the development and… Expand
Functional Domains of the Rsp5 Ubiquitin-Protein Ligase
ABSTRACT RSP5, an essential gene of Saccharomyces cerevisiae, encodes a hect domain E3 ubiquitin-protein ligase. Hect E3 proteins have been proposed to consist of two broad functional domains: a… Expand
Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530
Prostate cancer is the most frequently diagnosed cancer in American men. We have previously demonstrated that Src mediates androgen-independent proliferation in prostate cancer. We sought to… Expand
Clinical implications of neuroendocrine differentiation in prostate cancer
- E. C. Nelson, A. Cambio, J. Yang, J-H Ok, P. N. Lara, C. Evans
- Prostate Cancer and Prostatic Diseases
The cellular signaling pathways of the prostate play a central role in the induction, maintenance, and progression of prostate cancer (CaP). Neuroendocrine (NE) cells demonstrate attributes that… Expand
The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase.
- J. Huibregtse, J. Yang, S. Beaudenon
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 April 1997
The E3 ubiquitin-protein ligases play an important role in controlling substrate specificity of the ubiquitin proteolysis system. A biochemical approach was taken to identify substrates of Rsp5, an… Expand
Intracrine Androgens and AKR1C3 Activation Confer Resistance to Enzalutamide in Prostate Cancer.
The introduction of enzalutamide and abiraterone has led to improvement in the treatment of metastatic castration-resistant prostate cancer. However, acquired resistance to enzalutamide and… Expand
Human polymorphism at microRNAs and microRNA target sites.