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DAVID: Database for Annotation, Visualization, and Integrated Discovery
The distributed nature of biological knowledge poses a major challenge to the interpretation of genome-scale datasets, including those derived from microarray and proteomic studies. This reportExpand
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Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria
Mechanisms that regulate cellular metabolism are a fundamental requirement of all cells. Most eukaryotic cells rely on aerobic mitochondrial metabolism to generate ATP. Nevertheless, regulation ofExpand
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Inside the black box: The role and composition of compensation peer groups
This paper considers the features of the newly disclosed compensation peer groups and demonstrates their significant role in explaining variations in chief executive officer (CEO) compensation beyondExpand
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The endoplasmic reticulum gateway to apoptosis by Bcl-XL modulation of the InsP3R
Members of the Bcl-2 protein family modulate outer mitochondrial membrane permeability to control apoptosis. However, these proteins also localize to the endoplasmic reticulum (ER), the functionalExpand
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The Pan-STARRS1 Distant z > 5.6 Quasar Survey: More than 100 Quasars within the First Gyr of the Universe
Luminous quasars at z > 5.6 can be studied in detail with the current generation of telescopes and provide us with unique information on the first gigayear of the universe. Thus far, these studiesExpand
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Network model of survival signaling in large granular lymphocyte leukemia
T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling components thatExpand
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Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury.
Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe). This complex converts renal progenitors intoExpand
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Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN
Cytosolic foreign DNA is detected by pattern recognition receptors and mainly induces type I IFN production. We found that transfection of different types of DNA into various untreated cells inducesExpand
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Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice.
Epoxyeicosatrienoic acids (EETs) are small molecules produced by cytochrome P450 epoxygenases. They are lipid mediators that act as autocrine or paracrine factors to regulate inflammation andExpand
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An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein.
The human endogenous retrovirus K (HERV-K) family of endogenous retroviruses consists of approximately 50 proviral copies per haploid human genome. Herein, the HERV-Ks are shown to encode aExpand
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