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Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways.
TLDR
Findings indicate that E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes. Expand
Selective control of cortical axonal spikes by a slowly inactivating K+ current
TLDR
Data indicate that low-threshold, slowly inactivating K+ currents, containing Kv1.2 α subunits, play a key role in the flexible properties of intracortical axons and may contribute significantly to intracordical processing. Expand
Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis.
TLDR
Together, the results show that Twist1 needs to induce Snail2 to suppress the epithelial branch of the EMT program and that Twist2 and Twist1 act together to promote EMT and tumor metastasis. Expand
Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma.
TLDR
It is suggested that induction of Twist by a human viral oncoprotein LMP1 directly contributes to the metastatic nature of NPC. Expand
Structure of Arabidopsis HYPONASTIC LEAVES1 and its molecular implications for miRNA processing.
TLDR
Biochemical analyses suggest that HYL1 probably binds to the miRNA/miRNA region of precursors as a dimer mediated by HR2, andStructural and functional study demonstrates that both HR1 and TR2 are canonical dsRBDs for dsRNA binding, whereas HR2 ofHYL1 is a non-canonical dSRBD harboring a putative dimerization interface. Expand
Epidemiology of hand, foot, and mouth disease and genotype characterization of Enterovirus 71 in Jiangsu, China.
TLDR
Routine HFMD surveillance should be focused on the period of March-July, and more prevention efforts should be aimed at 1-4 years old children, as the C4a was the most prominent EV71 subgenotype circulating in China. Expand
The human glomerular podocyte is a novel target for insulin action.
TLDR
Novel conditionally immortalized human podocytes in vitro and human glomeruli ex vivo are reported that the podocyte, the principal cell responsible for prevention of urinary protein loss, is insulin responsive and able to approximately double its glucose uptake within 15 min of insulin stimulation. Expand
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia
TLDR
The present study explored the effect of AZD1152, a highly selective inhibitor of Aurora B kinase, on various types of human leukemia cells and found it to be a promising new agent for treatment of individuals with leukemia. Expand
Brentuximab vedotin demonstrates objective responses in a phase 2 study of relapsed/refractory DLBCL with variable CD30 expression.
TLDR
Overall, significant activity with brentuximab vedotin was observed in relapsed/refractory DLBCL, and responses occurred across a range of CD30 expression. Expand
Triptolide inhibits the growth and metastasis of solid tumors.
TLDR
Results suggest that TPL has several attractive features as a new antitumor agent, including induced apoptosis and reduced the expression of several molecules that regulate the cell cycle in cultured tumor cells. Expand
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