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Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates.
- D. M. Turner, R. Ransom, J. Yang, R. Olsen
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 March 1989
The steroid anesthetic alphaxalone and a series of naturally occurring analogs were compared in potency and efficacy with each other and the hypnotic barbiturate pentobarbital for interaction with… Expand
Endothelial potentiation of relaxation response to ascorbic acid in rat and guinea pig thoracic aorta.
The role of the endothelium was evaluated in the relaxation of rat and guinea pig aortic rings induced by ascorbic acid. Ascorbic acid relaxed rat and guinea pig aortic rings that were previously… Expand
[Studies on the chemical constituents of Arctium lappa L].
Six compounds were isolated from the seeds of Arctium lappa L. One of them is a new lignan named neoarctin B(VI). The structure has been elucidated on the basis of spectral (UV, IR, 1H-NMR, 13C-NMR,… Expand
A novel N6-substituted adenosine isolated from mi huan jun (Armillaria mellea) as a cerebral-protecting compound.
Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay of the effect on complete ischemia in mice, led to the isolation of a new compound with cerebral… Expand
Interaction of peptide fragment 828-848 of the envelope glycoprotein of human immunodeficiency virus type I with lipid bilayers.
The interaction of the peptide fragment 828-848, called P828, from the carboxy-terminal region of the envelope glycoprotein gp41 of HIV-I with model membranes composed of phosphatidylcholine (PC) and… Expand
Effects of interpenetration of thermo-sensitive gels by crosslinking of chitosan on nasal delivery of insulin: In vitro characterization and in vivo study
Abstract This investigation examines the in vitro release of insulin in new thermo-response P-CS/GA/Gly gels, in which a chitosan (CS), crosslinked using glutaraldehyde (GA), interpenetrates… Expand
Armillaric acid, a new antibiotic produced by Armillaria mellea.
A new antibiotic armillaric acid (2), has been isolated from the cultured mycelia of Armillaria mella (Vahl. ex Fr.) Quel (Trichlometaceae). Its structure was elucidated on the basis of the spectral… Expand
[Studies on the constituents of Aquilaria sinensis (Lour.) Gilg. I. Isolation and structure elucidation of two new sesquiterpenes, baimuxinic acid and baimuxinal].
[Studies on the chemical constituents of Aquilaria sinensis(Lour.) Gilg. IV. Isolation and characterization of 2-(2-phenylethyl)chromone derivatives].
Six chromone derivatives were isolated from the ether soluble fraction of the alcoholic extract of Aquilaria sinensis(Lour.) Gilg. (Thymeleaceae) by silica gel chromatography. On the basis of… Expand
[Chemical studies on the alkaloids of Hu-Man-Teng (Gelsemium elegans Banth.). I. Isolation of the alkaloids and structure of humantenmine].