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Estrogen carcinogenesis in breast cancer.
n this article, we review recent findings related to estrogen exposure and the risk of breast cancer, the mechanisms that may be involved, and the clinical implications of these findings. The weight… Expand
Molecular mechanisms of estrogen carcinogenesis.
In western society, the causes of several cancers--including breast, endometrium, ovary, liver, and prostate--have been linked to inappropriate and/or prolonged exposure to synthetic or endogenous… Expand
An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.
Mounting evidence suggests that catechol metabolites of estradiol may contribute to the development of estrogen-induced cancers. O-Methylation, catalyzed by catechol-O-methyltransferase (COMT),… Expand
Endogenous estrogens as carcinogens through metabolic activation.
- J. Yager
- Journal of the National Cancer Institute…
A common thread linking the main risks for developing breast cancer in women is cumulative, excessive exposure to estrogen. The standard paradigm to account for this association focuses on increased… Expand
The role of polyamine catabolism in polyamine analogue-induced programmed cell death.
- H. Ha, P. Woster, J. Yager, R. Casero
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 14 October 1997
N1-ethyl-N11-[(cyclopropyl)methyl]-4,8,-diazaundecane (CPENSpm) is a polyamine analogue that represents a new class of antitumor agents that demonstrate phenotype-specific cytotoxic activity.… Expand
Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications.
- Jin-qiang Chen, P. Cammarata, C. Baines, J. Yager
- Medicine, Biology
- Biochimica et biophysica acta
- 1 October 2009
There has been increasing evidence pointing to the mitochondrial respiratory chain (MRC) as a novel and important target for the actions of 17beta-estradiol (E(2)) and estrogen receptors (ER) in a… Expand
Serum concentrations of organochlorine compounds and the subsequent development of breast cancer.
- K. Helzlsouer, A. Alberg, +9 authors G. Comstock
- Cancer epidemiology, biomarkers & prevention : a…
- 1 June 1999
A nested case-control study was conducted to examine the association between serum concentrations of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), the primary metabolite of… Expand
Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells.
- J. Chen, M. Delannoy, C. Cooke, J. Yager
- American journal of physiology. Endocrinology and…
We observed previously that estrogen treatment increased the transcript levels of several mitochondrial DNA (mtDNA)-encoded genes for mitochondrial respiratory chain (MRC) proteins and MRC activity… Expand
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.
Systemic toxicity testing forms the cornerstone for the safety evaluation of substances. Pressures to move from traditional animal models to novel technologies arise from various concerns, including:… Expand
Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans.
- S. Rohrmann, W. Nelson, +5 authors E. Platz
- The Journal of clinical endocrinology and…
- 15 April 2006
CONTEXT Higher testosterone in black compared with white men has been postulated to explain their higher prostate cancer incidence. Previous studies comparing hormone levels by race might have been… Expand