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Estrogen carcinogenesis in breast cancer.
Insight into the mechanisms of the causation of cancer by estrogen will identify determinants of susceptibility to breast cancer and new targets for prevention and therapeutic intervention.
Molecular mechanisms of estrogen carcinogenesis.
The examples demonstrate that the parent compounds and their metabolites cause both nongenotoxic cell proliferative effects as well as direct and indirect genotoxic effects, which illustrates the complex nature of estrogen carcinogenesis.
An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.
The findings suggest that the allele encoding low activity COMT may be an important contributor to the postmenopausal development of breast cancer in certain women.
Endogenous estrogens as carcinogens through metabolic activation.
- J. Yager
- BiologyJournal of the National Cancer Institute…
It is concluded that factors will have to be identified through additional mechanistic studies and that, as they are identified, they can be incorporated into future molecular epidemiologic studies designed to determine their actual impact on cancer risk in human populations.
Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications.
Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells.
- Jin Q. Chen, Michael. Delannoy, C. Cooke, J. Yager
- BiologyAmerican journal of physiology. Endocrinology and…
It is found that E(2) significantly enhanced the amounts of mitochondrial ERalpha and ERbeta in a time- and concentration-dependent manner and that these effects are accompanied by a significant increase in the transcript levels of mtDNA-encoded genes, i.e., cytochrome c oxidase subunits I and II.
Serum concentrations of organochlorine compounds and the subsequent development of breast cancer.
- K. Helzlsouer, A. Alberg, G. Comstock
- MedicineCancer epidemiology, biomarkers & prevention : a…
- 1 June 1999
Exposure to relatively high concentrations of DDE or PCBs showed no evidence of contributing to an increased risk of breast cancer up to 20 years later, and these associations remained consistent regardless of lactation history and length of the follow-up interval.
Mitochondrial localization of ER and ER in human MCF7 cells
Using cellular fractionation and Western blot with ER - and ER -speciﬁc antibodies, it is observed that ER and ER are present in mitochondria of human MCF7 cells and that themitochondrial ER andERG account for 10 and 18%, respectively, of total cellular ER andER in 17 -estradiol cells.
Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans.
- S. Rohrmann, W. Nelson, E. Platz
- MedicineJournal of Clinical Endocrinology and Metabolism
- 15 April 2006
Contrary to the postulated racial difference, testosterone concentrations did not differ notably between black and white men, however, blacks had higher estradiol levels and Mexican-Americans had higher testosterone than whites but similar Estradiol and SHBG concentrations.
DNA damage caused by reactive oxygen species originating from a copper-dependent oxidation of the 2-hydroxy catechol of estradiol.
The results suggest that the oxidative damage results from the localized generation of singlet oxygen or a similar bound reactive entity rather than free hydroxyl radical in the presence of H2O2/Cu(II) system.