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Cloning and sequence analysis of the cDNA for human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.
- C. Ensor, J. Y. Yang, R. Okita, H. Tai
- Medicine, Biology
- The Journal of biological chemistry
- 5 September 1990
Isolation of the cDNA for 15-hydroxyprostaglandin dehydrogenase should facilitate studies on the structure, function, and regulation of this enzyme. Expand
Effect of carbonyl cyanide m-chlorophenylhydrazone (CCCP) on the dimerization of lipoprotein lipase.
Investigation of the dimerization status of LPL in 3T3-L1 adipocytes using sucrose density gradient ultracentrifugation and carbonyl cyanide m-chlorophenylhydrazone (CCCP), an inhibitor of ER-Golgi protein transport suggests that diming can occur in ER of CCCP-treated cells without acquisition of catalytic activity. Expand
Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice
Genetic deficiency of Ar significantly ameliorated development of key endpoints linked with early diabetic nephropathy in vivo, and robust and specific inhibition of aldose reductase might be an effective strategy for the prevention and treatment of diabetic neephropathy. Expand
Glycosylation of lipoprotein lipase in human subcutaneous lipomas.
- J. Park, J. Y. Yang, +5 authors H. Kim
- Chemistry, Medicine
- Hormone and metabolic research = Hormon- und…
Results suggest that partially sensitive subunits constitute the major secretable form of LPL in human subcutaneous lipomas. Expand
Monoclonal antibodies to human renal basement membranes: heterogenic and ontogenic changes.
These studies provide the foundation for further studies that will permit mapping and characterization of immunoreactive basement membrane components and changes in the distribution of antigens identified by other monoclonal antibodies were observed during ontogenesis. Expand
Glycosylation, dimerization, and heparin affinity of lipoprotein lipase in 3T3-L1 adipocytes.
Results suggest that core glycosylation and subsequent removal of glucose residue is required, but processing after Golgi mannosidase I is not necessary for dimerization and acquisition of high heparin affinity of LPL. Expand