The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6
- Shu-Chiun Sung, C. Chao, K. Jeng, J.-Y. Yang, M. Lai
- Biology, ChemistryVirology
- 21 March 2009
A novel long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1α in pancreatic ductal adenocarcinoma
Long non-coding RNA ENST00000480739 may provide not only a therapeutic potential to suppress metastasis but it may also be a novel biomarker for risk prognostication and personal therapy screening of PDAC patients.
Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKCζ pathway
- Ming Wei Wu, M. R. Kim, Y-S Chen, J.-Y. Yang, C-J Chang
- BiologyOncogene
- 20 February 2017
The data reveal that pharmacological concentration of ATRA effectively downregulates PKCζ through activation of miR-200c, leading to a decrease of the stem cell-like populations from non-tumorigenic mammary epithelial cells and non-aggressive breast cancer cells.
Long noncoding RNA ZFPM2-AS1 promotes the tumorigenesis of renal cell cancer via targeting miR-137.
- J-G Liu, Hb Wang, G. Wan, M-Z Yang, X-J Jiang, J.-Y. Yang
- BiologyEuropean Review for Medical and Pharmacological…
- 1 July 2019
The findings indicated that ZFPM2-AS1 could promote metastasis and proliferation, whereas inhibiting the apoptosis of RCC via targeting miR-137 via targeting microsatellite instability assay might provide a new vision for interpreting the mechanism of R CC development.
Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling
Gambogic acid sensitises lung cancer cells to CDDP in vitro and in vivo in NSCLC through inactivation of NF-κB and MAPK/HO-1 signalling pathways, providing a rationale for the combined use of CDDP and GA in lung cancer chemotherapy.
Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing α-tubulin acetylation in breast cancer
- Xiao-Hong Liao, J-G Wang, P. Zhou
- BiologyCell Death and Disease
- 1 May 2016
This study demonstrates that overexpression of APOC1P1-3 can inhibit breast cancer apoptosis, and it was found that 224 lncRNAs were upregulated in breast cancer, whereas 324 were downregulated.
LncRNA DARS-AS1 regulates microRNA-129 to promote malignant progression of thyroid cancer.
- W. Zheng, X. Tian, G. Tian
- Biology, MedicineEuropean Review for Medical and Pharmacological…
- 1 December 2019
DARS-AS1 level in tumor tissues of thyroid cancer was remarkably increased and was correlated with the pathological stage, distant metastasis, and poor prognosis of thyroid cancers.
SL4, a chalcone‐based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPK signalling pathway
SL4, a chalcone‐based compound, exhibits clearly inhibitory effects on HIF‐1 and has been shown to effectively suppress tumour invasion and angiogenesis in vitro and in vivo. Here, studies were…
Casticin induces apoptosis and mitotic arrest in pancreatic carcinoma PANC-1 cells
- Chuan Ding, Muhammad Khan, B. Zheng, J.-Y. Yang, Lili Zhong, T. Ma
- Medicine, Biology
- 15 February 2012
It is shown for the first time that casticin strongly inhibits the growth of PANC-1 pancreatic carcinoma cells and may be a promising candidate for treating human pancreatic cancer.
Hsa_circ_0124055 and hsa_circ_0101622 regulate proliferation and apoptosis in thyroid cancer and serve as prognostic and diagnostic indicators.
- J-W Sun, S. Qiu, J.-Y. Yang, X. Chen, H-X Li
- Biology, MedicineEuropean Review for Medical and Pharmacological…
- 1 April 2020
Both hsa_circ_0124055 and hsa-circ-0101622 could facilitate the prognosis and diagnosis of thyroid cancer, and function as the therapeutic targets for clinical practice.
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