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An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells
The IL-2/IL-2R signaling pathway has an important role in autoimmunity. Several genes identified in genome-wide association (GWA) studies encode proteins in the IL-2/IL-2R signaling cascade that are… Expand
Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study
- A. Reiner, C. Carty, +12 authors D. Nickerson
- Biology, Medicine
- Journal of thrombosis and haemostasis : JTH
- 1 June 2006
Summary. Background: Previous genotype–phenotype association studies of fibrinogen have been limited by incomplete knowledge of genomic sequence variation within and between major ethnic groups in… Expand
Genome‐wide Linkage Scan for the Metabolic Syndrome: The GENNID Study
In the United States, the metabolic syndrome (MetS) constitutes a major public health problem with over 47 million persons meeting clinical criteria for MetS. Numerous studies have suggested genetic… Expand
Risk prediction for complex diseases: application to Parkinson disease
Purpose:The aim of this study was to evaluate the risk of Parkinson disease using clinical and demographic data alone and when combined with information from genes associated with Parkinson… Expand
Screening efficient siRNAs in vitro as the candidate genes for chicken anti-avian influenza virus H5N1 breeding
The frequent disease outbreaks caused by avian influenza virus (AIV) not only affect the poultry industry but also pose a threat to human safety. To address the problem, RNA interference (RNAi) has… Expand
Association mapping of the PARK10 region for Parkinson's disease susceptibility genes.
BACKGROUND Previous studies indicate that as many as six genes within the PARK10 region (RNF11, UQCRH, HIVEP3, EIF2B3, USP24, ELAVL4) might modify susceptibility or age at onset in Parkinson's… Expand
A comparison between acute exposures to ethanol and acetaldehyde on neurotoxicity, nitric oxide production and NMDA-induced excitotoxicity in primary cultures of cortical neurons.
Chronic exposure of primary neuronal cultures to ethanol has been shown to potentiate N-methyl-D-aspartate (NMDA) receptor-mediated processes, such as nitric oxide (NO) formation and excitotoxicity.… Expand
Multivariate Linkage Scan for Metabolic Syndrome Traits in Families With Type 2 Diabetes
- K. Edwards, J. Y. Wan, C. Hutter, P. Y. Fong, Stephanie A. Santorico
- Biology, Medicine
- 1 June 2011
The purpose of this study was to evaluate evidence for linkage to interrelated quantitative features of the metabolic syndrome (MetS). Data on eight quantitative MetS traits (body weight, waist… Expand