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Vedolizumab as induction and maintenance therapy for ulcerative colitis.
Vedolizumab was more effective than placebo as induction and maintenance therapy for ulcerative colitis and the frequency of adverse events was similar in the vedolIZumab and placebo groups.
Species differences and molecular determinant of TRPA1 cold sensitivity
It is shown that cold activates rat and mouse TRPA1 but not human or rhesus monkey TRPA 1, and a single residue within the S5 transmembrane domain accounts for the observed difference in cold sensitivity.
Evaluation of combined antibacterial effects of eugenol, cinnamaldehyde, thymol, and carvacrol against E. coli with an improved method.
The negative impacts of unpleasant smell of eugenol, cinnamaldehyde, thymol, and carvacrol could be minimized, making it possible to add them to foods as preservatives.
Application of dispersive liquid-liquid microextraction and high-performance liquid chromatography for the determination of three phthalate esters in water samples.
Inhibition of autophagy enhances the anticancer activity of silver nanoparticles
It is shown that Ag NPs induced autophagy in cancer cells by activating the PtdIns3K signaling pathway, and wortmannin, a widely used inhibitor of autophagosome formation, significantly enhanced the antitumor effect of Ag Nps in the B16 mouse melanoma cell model.
Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death.
- M. Alonso, Hong Jiang, J. Fueyo
- Biology, MedicineMolecular therapy : the journal of the American…
- 1 March 2008
This is the first report showing that Delta-24-RGD plus RAD001 causes autophagic cell death, and dramatically increases long-term survival rates of glioma-bearing animals, and synergistically enhanced by combination with RAD001.
Changing spectrum of biopsy-proven primary glomerular diseases over the past 15 years: a single-center study in China.
PGD has remained the most common renal disease in China, although with a descending trend, and the spectrum of PGD is different in different age groups.
Potential health risks of heavy metals in cultivated topsoil and grain, including correlations with human primary liver, lung and gastric cancer, in Anhui province, Eastern China.
Chronic and Acute Models of Retinal Neurodegeneration TrkA Activity Are Neuroprotective whereas p75NTR Activity Is Neurotoxic through a Paracrine Mechanism*
- Yu-jing Bai, P. Dergham, H. Saragovi
- Biology, MedicineThe Journal of Biological Chemistry
- 13 October 2010
Data reveal a balance of neuroprotective and neurotoxic mechanisms in normal and diseased retinas, and validate each neurotrophin receptor as a pharmacological target for neuroprotection.
Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1…