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An overview of the regulation of bone remodelling at the cellular level.
OBJECTIVES To review the current literature on the regulation of bone remodelling at the cellular level. DESIGN AND METHODS The cellular activities of the cells in the basic multicellular unitExpand
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Scaffolds for tendon and ligament repair: review of the efficacy of commercial products
Driven by market demand, many biological and synthetic scaffolds have been developed during the last 15 years. Both positive and negative results have been reported in clinical applications forExpand
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Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAsExpand
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Current research on pharmacologic and regenerative therapies for osteoarthritis
Osteoarthritis (OA) is a degenerative joint disorder commonly encountered in clinical practice, and is the leading cause of disability in elderly people. Due to the poor self-healing capacity ofExpand
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The chondrocyte: biology and clinical application.
Chondrocyte is a unique cell type in articular cartilage tissue and is essential for cartilage formation and functionality. It arises from mesenchymal stem cells (MSCs) and is regulated by a seriesExpand
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Gene expression profiles of human chondrocytes during passaged monolayer cultivation
Chondrocyte phenotype has been shown to dedifferentiate during passaged monolayer cultivation. Hence, we have investigated the expression profile of 27 chondrocyte‐associated genes from bothExpand
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Sesquiterpene Lactone Parthenolide Blocks Lipopolysaccharide‐Induced Osteolysis Through the Suppression of NF‐κB Activity
Effective treatment for bacteria‐induced bone lytic diseases is not yet available. In this study, we showed that PAR, an NF‐κB inhibitor found in medicinal herbs, can block LPS‐induced osteolysis.Expand
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Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, andExpand
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microRNA‐103a Functions as a Mechanosensitive microRNA to Inhibit Bone Formation Through Targeting Runx2
Emerging evidence indicates that microRNAs (miRNAs) play essential roles in regulating osteoblastogenesis and bone formation. However, the role of miRNA in osteoblast mechanotransduction remains toExpand
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A Novel Mutation (K378X) in the Sequestosome 1 Gene Associated With Increased NF‐κB Signaling and Paget's Disease of Bone With a Severe Phenotype
Sequestosome 1/p62 (p62) mutations are associated with PDB; however, there are limited data regarding functional consequences. We report a novel mutation in exon 7 (K378X) in a patient withExpand
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