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Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial.
BACKGROUND Most cases of hepatocellular carcinoma occur in the Asia-Pacific region, where chronic hepatitis B infection is an important aetiological factor. Assessing the efficacy and safety of newExpand
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Human health risk assessment of heavy metals in soil-vegetable system: a multi-medium analysis.
Vegetable fields near villages in China are suffering increasing heavy metal damages from various pollution sources including agriculture, traffic, mining and Chinese typical local privateExpand
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Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction.
  • Jin Li, S. Qin, +31 authors H. Yu
  • Medicine
  • Journal of clinical oncology : official journal…
  • 27 September 2016
PURPOSE There is currently no standard treatment strategy for patients with advanced metastatic gastric cancer experiencing progression after two or more lines of chemotherapy. We assessed theExpand
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Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.
The in vivo biological function of a steroid receptor coactivator was assessed in mice in which the SRC-1 gene was inactivated by gene targeting. Although in both sexes the homozygous mutants wereExpand
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Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind,
BACKGROUND In the international randomised phase 3 CORRECT trial (NCT01103323), regorafenib significantly improved overall survival versus placebo in patients with treatment-refractory metastaticExpand
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Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family
The three homologous members of the p160 SRC family (SRC1, SRC2 and SRC3) mediate the transcriptional functions of nuclear receptors and other transcription factors, and are the most studied of allExpand
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Identification of trace element sources and associated risk assessment in vegetable soils of the urban-rural transitional area of Hangzhou, China.
In the urban-rural transitional area of Hangzhou, China, 74 topsoil samples were collected from vegetable fields to measure the contents of arsenic (As), copper (Cu), cobalt (Co), cadmium (Cd),Expand
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Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity.
MKK4 is a member of the mitogen-activated protein kinase kinase group of dual specificity protein kinases that functions as an activator of the c-Jun NH2-terminal kinase (JNK) in vitro. To examineExpand
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Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms
This article reviews the molecular structure, expression pattern, physiological function, pathological roles and molecular mechanisms of Twist1 in development, genetic disease and cancer. Twist1 is aExpand
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Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial.
  • Jin Li, S. Qin, +15 authors H. Yu
  • Medicine
  • Journal of clinical oncology : official journal…
  • 10 September 2013
PURPOSE Patients with metastatic gastric cancer (mGC) who do not respond to or who experience progression with second-line chemotherapy have no treatment options that clearly confer a survivalExpand
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