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Microbial iron transport via a siderophore shuttle: a membrane ion transport paradigm.
TLDR
It is shown that the siderophore and Fe(3+) enter the bacterium together, a ligand exchange step occurs in the course of the transport, and a redox process is not involved in iron exchange.
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New agents for in vivo chelation of uranium(VI): efficacy and toxicity in mice of multidentate catecholate and hydroxypyridinonate ligands.
TLDR
Considering low toxicity, effectiveness, and reasonable cost, the structurally simple linear tetradentate ligands based on the 5-LI backbone (diaminopentane) offer the most promising approach to a clinically acceptable therapeutic agent for U(VI.
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Development of Decorporation Agents for the Actinides
Chelation therapy for internally deposited actinides has been shown to reduce acute radiation damage and chemical toxicity and the severity of late radiation effects. This review traces the…
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Plutonium(IV) sequestration: structural and thermodynamic evaluation of the extraordinarily stable cerium(IV) hydroxypyridinonate complexes.
TLDR
From the formation constants and from the protonation constants of the ligands, extraordinarily high pM values for Ce(IV) are generated by these tetradentate ligands.
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Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala-->Ser and Val-->Thr substitutions in T4 lysozyme.
TLDR
The results are consistent with the view that many hydrogen bonds within proteins contribute only marginally to stability but that noncharged polar groups that lack a hydrogen-bonding partner are very destabilizing.
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Syntheses and relaxation properties of mixed gadolinium hydroxypyridinonate MRI contrast agents.
TLDR
A mechanism for the rapid rates of water exchange is proposed involving a low energy barrier between the 8- and 9-coordinate geometries for lanthanide complexes of HOPO-based ligands of novel mixed ligand systems based on the TREN-Me-3,2-HOPO platform.
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Specific sequestering agents for the actinides. 28. Synthesis and initial evaluation of multidentate 4-carbamoyl-3-hydroxyl-1-methyl-2(1H)-pyridinone ligands for in vivo plutonium(IV) chelation.
TLDR
Observations suggest that even the tetradentate Me-3,2-HOPO ligands compete with mammalian transferrin for Pu(IV), and three of these compounds studied have low toxicity and are relatively simple and inexpensive to prepare.
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The hexadentate hydroxypyridinonate TREN-(Me-3,2-HOPO) is a more orally active iron chelator than its bidentate analogue.
TLDR
Results support the hypothesis that greater Fe chelation efficiency can be achieved with hexadentate than with bidentate chelators at lower, and presumably safer, concentrations and demonstrate that TREN-(Me-3, 2-HOPO) is a promising, orally effective, Fe chelator.
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237Np: oxidation state in vivo and chelation by multidentate catecholate and hydroxypyridinonate ligands.
TLDR
The results indicate that: the dominant neptunium species circulating and excreted in urine is Np(V), while that in bone and liver deposits is Nn(IV); N p(V) must be reduced to Np (IV) before it can be stably chelated; efficient decorporation of nePTunium requires multidentate ligands that form exceptionally stable actinide(IV) chelates and facilitate Np.(V) reduction.
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Multidentate hydroxypyridinonate ligands for Pu(IV) chelation in vivo: comparative efficacy and toxicity in mouse of ligands containing 1,2-HOPO or Me-3,2-HOPO.
TLDR
Nine HOPO ligands, promptly injected or given orally or injected at low dosage, are superior to CaNa3-DTPA for reducing 238Pu retention in mouse and the most efficacious ligand, 3,4,3-LI(1,2-HOPO), contains the less stably binding 1, 2-HopO group, which must confer advantages for Pu(IV) binding.
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