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Extracellular histones are major mediators of death in sepsis
It is concluded that extracellular histones are potential molecular targets for therapeutics for sepsis and other inflammatory diseases. Expand
Arabidopsis DCP2, DCP1, and VARICOSE Form a Decapping Complex Required for Postembryonic Development[W]
It is shown that Arabidopsis thaliana DCP2 can generate from capped mRNAs, m7GDP, and 5′-phosphorylated m RNAs in vitro and that this decapping activity requires an active Nudix domain, suggesting that mRNA turnover mediated by the decapping complex is required for postembryonic development inArabidopsis. Expand
Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
It is shown that pluripotent stem cells can be generated from mouse somatic cells at a frequency up to 0.2% using a combination of seven small-molecule compounds, which resemble embryonic stem cells in terms of their gene expression profiles, epigenetic status, and potential for differentiation and germline transmission. Expand
Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury
The studies imply that histone release contributes to death in inflammatory injury and in chemical-induced cellular injury, both of which are mediated in part through the TLRs. Expand
Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis
Direct evidence is provided that SARS human coronavirus is capable of infecting the central nervous system, and that Mig might be involved in the brain immunopathology of SARS. Expand
Sex differences in sex chromosome gene expression in mouse brain.
Three X-Y gene pairs appeared to be differentially regulated (expressed in brain in a different age- or tissue-dependent pattern), and hence may not be functionally equivalent and suggest several mechanisms by which these genes may participate in sex differences in brain development and function. Expand
Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation
  • J. Xu, N. Chua
  • Biology, Medicine
  • The EMBO journal
  • 18 April 2012
It is shown that dehydration stress activated MPK6 to phosphorylate serine 237 of Arabidopsis DCP1 and phospho‐DCP1 preferentially associated with DCP5 to promote mRNA decapping in vivo to serve as a rapid response to dehydration stress inArabidopsis. Expand
Intestinal fungi contribute to development of alcoholic liver disease
It is demonstrated that chronic alcohol administration increases mycobiota populations and translocation of fungal &bgr;-glucan into systemic circulation in mice and Manipulating the intestinalMycobiome might be an effective strategy for attenuating alcohol-related liver disease. Expand
TRIP6 Enhances Lysophosphatidic Acid-induced Cell Migration by Interacting with the Lysophosphatidic Acid 2 Receptor*
This work shows that LPA stimulation promotes the interaction of the LPA2 receptor with a focal adhesion molecule, TRIP6 (thyroid receptor interacting protein 6)/ZRP-1 (zyxin-related protein 1), and suggests that TRIP 6 functions at a point of convergence between the activated L PA2 receptor and downstream signals involved in cell adhesion and migration. Expand
Serial Expression Analysis of Liver Regeneration-Related Genes in Rat Regenerating Liver
Investigation of gene expression changes in rat hepatic restoration with Rat Genome 230 2.0 chip indicated that cell apoptosis and inflammatory response were enhanced in the initial phase and the early part of progressive phase in LR. Expand