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Effects of normal meals rich in carbohydrates or proteins on plasma tryptophan and tyrosine ratios.
- R. Wurtman, J. Wurtman, M. Regan, J. McDermott, R. Tsay, J. Breu
- Chemistry, Medicine
- The American journal of clinical nutrition
Whether carbohydrate-rich or protein-rich breakfasts, such as those Americans normally eat, produce substantial differences in the plasma tryptophan-LNAA ratio and in the corresponding ratio for tyrosine, the precursor of brain dopamine and norepinephrine is determined. Expand
Effect of nutrient intake on premenstrual depression.
- J. Wurtman, A. Brzezinski, R. Wurtman, B. Laferrère
- American journal of obstetrics and gynecology
- 1 November 1989
Consumption of a carbohydrate-rich, protein-poor evening test meal during the late luteal phase of the menstrual cycle improved depression, tension, anger, confusion, sadness, fatigue, alertness, and calmness scores among patients with premenstrual syndrome. Expand
Changes in mood after carbohydrate consumption among obese individuals.
It is suggested that snacking habits of obese individuals may be related to subsequent mood states, and noncarbohydrate cravers experienced an increase in depression, while carbohydrate cravers reported feeling less depressed. Expand
Effects of protein and carbohydrate meals on mood and performance: interactions with sex and age.
Positive effects on concentration when older subjects consume a high-carbohydrate, low-protein lunch are suggested and appear to arise predominantly from lapses of attention rather than from intrusion of distractors. Expand
The involvement of brain serotonin in excessive carbohydrate snacking by obese carbohydrate cravers.
- J. Wurtman
- Journal of the American Dietetic Association
- 1 September 1984
Evidence is presented that carbohydrate snacking seems to be related to a "need" to increase the level of brain serotonin; treatment with a drug, d-1 fenfluramine, that increases serotoninergic neurotransmission significantly decreases carbohydrate snack consumption. Expand
Brain serotonin, carbohydrate-craving, obesity and depression.
Dexfenfluramine constitutes a highly effective treatment for patients with normal-weight bulimia, in addition to producing its general satiety-promoting effect, it specifically reduces their overconsumption of carbohydrate-rich (or carbohydrate-and fat-rich) foods. Expand
Do carbohydrates affect food intake via neurotransmitter activity?
A group of diseases seems to exist in which depressive symptoms are associated with "carbohydrate-craving", and the consumption of large quantities of carbohydrate-rich, protein-poor snacks, which may be mediated by the rise in brain serotonin. Expand
The Trajectory from Mood to Obesity
The obesity caused by drugs or mood disorders associated with “carbohydrate craving” leading to excess calorie intake can be suppressed by dietary measures. Expand
Fenfluramine and fluoxetine spare protein consumption while suppressing caloric intake by rats.
Observations indicate that two distinct brain mechanisms, sensitive to different drugs, underlie the elective consumption of protein and calories. Expand
Drugs that enhance central serotoninergic transmission diminish elective carbohydrate consumption by rats.
Evidence is presented that rats given diet mixtures containing various proportions of carbohydrates have the ability to regulate their carbohydrate intakes, and that this ability is independent of whether or not the carbohydrate consumed has a sweet taste. Expand