• Publications
  • Influence
Signal Transduction in Neuronal Migration Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway
The Slit protein guides neuronal and leukocyte migration through the transmembrane receptor Roundabout (Robo). We report here that the intracellular domain of Robo interacts with a novel family ofExpand
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Vertebrate Slit, a Secreted Ligand for the Transmembrane Protein Roundabout, Is a Repellent for Olfactory Bulb Axons
The olfactory bulb plays a central role in olfactory information processing through its connections with both peripheral and cortical structures. Axons projecting from the olfactory bulb to theExpand
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Specific interactions between proteins implicated in splice site selection and regulated alternative splicing
Specific recognition and pairing of the 5' and 3' splice sites are critical steps in pre-mRNA splicing. We report that the splicing factors SC35 and SF2/ASF specifically interact with both theExpand
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Robo4 is a vascular-specific receptor that inhibits endothelial migration.
Guidance and patterning of axons are orchestrated by cell-surface receptors and ligands that provide directional cues. Interactions between the Robo receptor and Slit ligand families of proteinsExpand
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Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
Mutations in the gene encoding TDP-43—the major protein component of neuronal aggregates characteristic of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) withExpand
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The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors
Migration is a basic feature of many cell types in a wide range of species. Since the 1800s, cell migration has been proposed to occur in the nervous and immune systems, and distinct molecular cuesExpand
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Directional guidance of neuronal migration in the olfactory system by the protein Slit
Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronalExpand
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Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction
Although netrins are an important family of neuronal guidance proteins, intracellular mechanisms that mediate netrin function are not well understood. Here we show that netrin-1 induces tyrosineExpand
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A Drosophila model for TDP-43 proteinopathy
  • Y. Li, P. Ray, +6 authors J. Wu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 26 January 2010
Neuropathology involving TAR DNA binding protein-43 (TDP-43) has been identified in a wide spectrum of neurodegenerative diseases collectively named as TDP-43 proteinopathy, including amyotrophicExpand
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Cellular and Molecular Guidance of GABAergic Neuronal Migration from an Extracortical Origin to the Neocortex
Formation of the normal mammalian cerebral cortex requires the migration of GABAergic inhibitory interneurons from an extracortical origin, the lateral ganglionic eminence (LGE). Mechanisms guidingExpand
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