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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
TLDR
Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin, providing evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. Expand
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.
TLDR
It is shown that TGF beta 1 LAP is a ligand for the integrin alpha vbeta 6 and that alpha v beta 6-expressing cells induce spatially restricted activation of TGFbeta 1. Expand
Progressive Differentiable Architecture Search: Bridging the Depth Gap Between Search and Evaluation
TLDR
This paper presents an efficient algorithm which allows the depth of searched architectures to grow gradually during the training procedure, and solves two issues, namely, heavier computational overheads and weaker search stability, which are solved using search space approximation and regularization. Expand
Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins
TLDR
This work provides new insight into how a stress response pathway can be structured to allow cells to avert death as they adapt and underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome. Expand
Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response
TLDR
The studies delineate a molecular mechanism for activation of an ER-localized transcription factor, CREBH, and reveal an unprecedented link by which ER stress initiates an acute inflammatory response. Expand
Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
TLDR
It is shown that DAP12, a disulphide-bonded homodimer containing an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain, non-covalently associates with membrane glycoproteins of the killer-cell inhibitory receptor (KIR) family without an ITIM in their cy toplasmaic domain. Expand
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress.
TLDR
The results suggest that the vertebrate ATF6alpha pathway evolved to maintain ER function when cells are challenged with chronic stress and provide a rationale for the overlap among the three UPR pathways. Expand
The genome of the pear (Pyrus bretschneideri Rehd.).
TLDR
The draft genome of the pear using a combination of BAC-by-BAC and next-generation sequencing is reported, and size differences between the apple and pear genomes are confirmed mainly due to the presence of repetitive sequences predominantly contributed by transposable elements (TEs), while genic regions are similar in both species. Expand
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.
TLDR
An unanticipated direct link between ER homeostasis and the transcriptional regulation of metabolism is revealed, and mechanisms by which ER stress might underlie fatty liver disease are suggested. Expand
A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy
TLDR
A form of PGC-1α (PGC-1 α4) that results from alternative promoter usage and splicing of the primary transcript is identified that regulates and coordinates factors involved in skeletal muscle hypertrophy. Expand
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