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Predicting the activity of phenolic antioxidants: theoretical method, analysis of substituent effects, and application to major families of antioxidants.
A procedure based on density functional theory is used for the calculation of the gas-phase bond dissociation enthalpy (BDE) and ionization potential for molecules belonging to the class of phenolicExpand
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Vulnerability to noise-induced hearing loss in ‘middle-aged’ and young adult mice: a dose–response approach in CBA, C57BL, and BALB inbred strains
Vulnerability of the cochlea to noise-induced permanent threshold shifts (NIPTS) was examined in young adult (1-2 months) and 'middle-aged' (5-7 months) CBA/CaJ, C57BL/6J, and BALB/cJ inbred mice.Expand
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Prooxidant and antioxidant activity of vitamin E analogues and troglitazone.
The order of antioxidant effectiveness of low concentrations of vitamin E analogues, in preventing cumene hydroperoxide-induced hepatocyte lipid peroxidation and cytotoxicity, wasExpand
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Development of novel antioxidants: design, synthesis, and reactivity.
We are attempting to develop novel synthetic antioxidants aimed at retarding the effects of free-radical induced cell damage. In this paper we discuss the design strategy and report the synthesis ofExpand
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Interaction force diagrams: new insight into ligand-receptor binding
A method is described to calculate and visualize the interaction forces of ligand-receptor complexes. Expand
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Oxidative modification of citrate synthase by peroxyl radicals and protection with novel antioxidants
In mammals, aging is linked to a decline in the activity of citrate synthase (CS; E.C., the first enzyme of the citric acid cycle. We used 2,2′-azobis(2-amidinopropane) dihydrochlorideExpand
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Investigation of residues Lys112, Glu136, His138, Gly247, Tyr248, and Asp249 in the active site of yeast cystathionine beta-synthase.
Cystathionine beta-synthase (CBS), the first enzyme of the reverse transsulfuration pathway, catalyzes the pyridoxal 5'-phosphate-dependent condensation of <span class="smallcap">l</span>-serine andExpand
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Naphthalene diols: a new class of antioxidants intramolecular hydrogen bonding in catechols, naphthalene diols, and their aryloxyl radicals.
1,8-Naphthalenediol, 5, and its 4-methoxy derivative, 6, were found to be potent H-atom transfer (HAT) compounds on the basis of their rate constants for H-atom transfer to theExpand
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Mechanism of cytotoxicity of catechols and a naphthalenediol in PC12-AC cells: the connection between extracellular autoxidation and molecular electronic structure.
ortho-Hydroxyphenols (catechols) form a common structural unit in naturally occurring antioxidants such as polyphenols. They also show pro-oxidant characteristics which depend on their particularExpand
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Plant phenolics regulate neoplastic cell growth and survival: a quantitative structure-activity and biochemical analysis.
The anti-tumour activities of many plant phenolics at high concentrations (>100 micromol/L) suggest their potential use as dietary supplements in cancer chemoprevention and cancer chemotherapy.Expand
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