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Linkage relationships reflecting ancestral tetraploidy in salmonid fish.
TLDR
Fifteen classical linkage groups were identified in two salmonid species and three fertile, interspecific hybrids by backcrossing multiply heterozygous individuals and these linkage relationships support the contention that all extant salmonids arose from a common tetraploid progenitor and that this progenitors may have been a segmental allotetraploids.
Growth, production and energy transformations in the salt-marsh killifish Fundulus heteroclitus
TLDR
Populations of Fundulus heteroclitus at the beginning of a growth season in a New England salt marsh consist of 3 yearly age classes, with the 1-year-old class contributing most of the biomass, a value among the highest obtained for natural fish populations.
Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response.
TLDR
These pharmacokinetic data support the premise that enhancement of cyclophosphamide activation may lead to both greater tumor cytotoxicity and increased but reversible end-organ toxicity.
Differences in low pH tolerance among strains of brook trout (Salvelinus fontinalis)
TLDR
It is likely that a strain resistant to a pH below 4.1, the previously recorded lower limit, can be developed by selective breeding.
Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and
TLDR
Results indicate that, in addition to their previously reported tight binding to dihydrofolate reductase, a property contributing to the high potency of PT523 and its B-ring analogs as inhibitors of tumor cell growth is their strong affinity for the RFC.
Effects of stable flies on weight gains and feed efficiency of calves on growing or finishing rations.
TLDR
Blood chemistry analysis and pathological examinations revealed no indication of calf stress induced by stable flies nor did pathological examinations reveal any detrimental conditions that might be caused by stable fly feeding.
Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
TLDR
Inhibition of H35 cell growth by PT523 was associated with a concentration- and time-related decrease in de novo dTMP and purine biosynthesis, suggesting that penetration of the cell probably involves, at least in part, active transport by the MTX/reduced folate carrier.
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