• Publications
  • Influence
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan. Expand
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
The hypothesis‐driven, bioinformatics‐based approach used to discover that dasatinib (D) and quercetin (Q) are senolytic can be extended to increase the repertoire ofsenolytic drugs, including additional cell type‐specific senolytics agents. Expand
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome
The results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. Expand
Extending the mutual information measure to rank inferred literature relationships
  • J. Wren
  • Computer Science, Medicine
  • BMC Bioinformatics
  • 7 October 2004
Mutual information calculations can be effectively extended into implied relationships and a significance cutoff estimated from analysis of random word networks and the shared minimum MIM (MMIM) model is found to correlate best with the observed strength and frequency of known associations. Expand
The write position
The number of authors per paper in PubMed is growing—so‐called ‘author inflation’, an increasing trend in many research fields largely owing to the increasing pressure to publish, specialization of research expertise, collaborative efforts and honorary authorships. Expand
Ska3 Is Required for Spindle Checkpoint Silencing and the Maintenance of Chromosome Cohesion in Mitosis
It is suggested that this network plays a major role in silencing the spindle checkpoint when chromosomes are aligned at metaphase to allow timely anaphase onset and mitotic exit. Expand
Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients.
The data suggest epigenetic "poising" of interferon-regulated genes in l upus naïve CD4+ T cells, argue for a novel pathogenic implication for abnormal T cell DNA methylation in lupus, and suggest a mechanism for type-I interferons hyper-responsiveness in lUPus T cells. Expand
Knowledge discovery by automated identification and ranking of implicit relationships
A computational method to identify relationships within scientific reports, such that large sets of relationships between unrelated items could be sought out and statistically ranked for their potential relevance as a set, demonstrates the method is well suited to discover novel relationships based upon existing shared relationships. Expand
Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus
Data suggest that the methylation status of RAB22A, STX1B2, LGALS3BP, DNASE1L1 and PREX1 correlates with disease activity in lupus patients, and protein-protein interaction maps identified a transcription factor, HNF4a, as a regulatory hub affecting a number of differentially methylated genes. Expand
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome‐Wide Association Study
This study was undertaken to perform the first unbiased genome‐wide association analysis of Takayasu arteritis, a rare large vessel vasculitis with incompletely understood etiology. Expand