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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
TLDR
In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes, seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Expand
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
TLDR
In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes and should be restricted to patients in whom there is a clear antimicrobial indication. Expand
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
TLDR
In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Expand
TOPICAL TRETINOIN IMPROVES THE APPEARANCE OF PHOTO DAMAGED SKIN
TLDR
It is concluded that tretinoin 0.05% cream significantly improved the appearance of photodamaged skin. Expand
A systematic review and critical evaluation of reported pathogenic sequence variants in hidradenitis suppurativa
TLDR
A systematic review of sequence variants in Hidradenitis suppurativa found a large number of variants of ‘uncertain significance’, largely due to the variable number of functional studies, which requires further research. Expand
Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study
TLDR
The prevalence of asthma and allergy in CRS varies by phenoytype, with CRSwNPs and AFRS having a stronger association with both and aspirin sensitivity has a highly significant association with AFRS. Expand
Narrowband ultraviolet B phototherapy in erythropoietic protoporphyria: case series
TLDR
It is suggested that the optimal dosing schedule for the use of infliximab in the treatment of HS is yet to be determined and that dermatologists should consider using dosing schedules for inflammatory joint and bowel disease in the management of patients severely affected with HS. Expand
SAPHO syndrome associated with hidradenitis suppurativa and pyoderma gangrenosum successfully treated with adalimumab and methotrexate: a case report and review of the literature
TLDR
Serum proinflammatory cytokine levels were significantly elevated and improved substantially after 3 months of therapy, and rationale for therapy in this patient was the observation that tumor necrosis alpha antagonists have been successfully used in SAPHO syndrome, and since arthropathy was so prominent in their patient, the authors elected to use adalimumab combined with methotrexate. Expand
Adopting the orphan: The importance of recognising hidradenitis suppurativa as a systemic auto‐inflammatory disease
TLDR
Doubtful value of patch testing for suspected contact allergy to ophthalmic products is found for periorbital dermatitis in 4779 patients – patch test results during a 10-year period. Expand
Phenotypic heterogeneity implies heterogeneous pathogenic pathways in hidradenitis suppurativa
TLDR
Hidradenitis Suppurativa is a chronic inflammatory condition manifesting in recurrent painful deep-seated nodules and abscesses with variable phenotypic presentations, and the role of adipose tissue as a dynamic endocrinological organ across all BMI ranges in HS requires further investigation. Expand
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