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A P2X purinoceptor expressed by a subset of sensory neurons
ATP is known to depolarize sensory neurons, and may play a role in nociceptor activation when released from damaged tissue1-10. Here we report the molecular cloning and characterization of a newExpand
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An SCN9A channelopathy causes congenital inability to experience pain
The complete inability to sense pain in an otherwise healthy individual is a very rare phenotype. In three consanguineous families from northern Pakistan, we mapped the condition as anExpand
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A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
DORSAL root ganglion sensory neurons associated with C-fibres, many of which are activated by tissue-damage, express an unusual voltage-gated sodium channel that is resistant to tetrodotoxin1–9. WeExpand
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The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium channels. Here we examined the role of the sensory-neuron-specific (SNS) TTX-resistant sodium channel α subunitExpand
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SCN9A Mutations in Paroxysmal Extreme Pain Disorder: Allelic Variants Underlie Distinct Channel Defects and Phenotypes
Paroxysmal extreme pain disorder (PEPD), previously known as familial rectal pain (FRP, or OMIM 167400), is an inherited condition characterized by paroxysms of rectal, ocular, or submandibular painExpand
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Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X 3 receptors
ATP activates damage-sensing neurons (nociceptors) and can evoke a sensation of pain. The ATP receptor P2X3 is selectively expressed by nociceptors and is one of seven ATP-gated, cation-selective ionExpand
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Potent analgesic effects of GDNF in neuropathic pain states.
Neuropathic pain arises as a debilitating consequence of nerve injury. The etiology of such pain is poorly understood, and existing treatment is largely ineffective. We demonstrate here that glialExpand
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The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain
Peripheral pain pathways are activated by a range of stimuli. We used diphtheria toxin to kill all mouse postmitotic sensory neurons expressing the sodium channel Nav1.8. Mice showed normal motorExpand
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Piezo2 is the major transducer of mechanical forces for touch sensation in mice
The sense of touch provides critical information about our physical environment by transforming mechanical energy into electrical signals. It is postulated that mechanically activated cation channelsExpand
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Nomenclature of Voltage-Gated Sodium Channels
Voltage-gated Ca2+ channels mediate calcium influx in response to membrane depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression.Expand
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