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Dual function of the selenoprotein PHGPx during sperm maturation.
The role of PHGPx as a structural protein may explain the mechanical instability of the mitochondrial midpiece that is observed in selenium deficiency. Expand
Plastid gene expression and plant development require a plastidic protein of the mitochondrial transcription termination factor family
Overall, the results indicate that biosynthesis of malonyl-CoA and plastid-derived systemic growth-promoting compounds are the processes that link plant development and plastsid gene expression. Expand
The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate
Surprisingly, the intracellular proteome of A. niger growing on xylose or maltose in well-aerated controlled bioreactor cultures differed more from a culture growing in shake flasks using the same medium than from theBioreactor culture growing on maltose. Expand
An efficient proteomics method to identify the cellular targets of protein kinase inhibitors
  • K. Godl, J. Wissing, +8 authors H. Daub
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 10 December 2003
Efficient affinity purification techniques can be developed for other protein kinase inhibitors, providing crucial information about their cellular modes of action and might have significant implications on the development of p38 inhibitors as antiinflammatory drugs. Expand
Cellular targets of gefitinib.
A proteomic method is used to profile the cellular targets of the clinical epidermal growth factor receptor kinase inhibitor gefitinib and suggestions are suggested that suggest alternative cellular modes of action for gefITinib. Expand
The F-actin Cross-linking and Focal Adhesion Protein Filamin A Is a Ligand and in Vivo Substrate for Protein Kinase Cα*
The data suggest an intimate interaction between filamin and PKC in cell signaling, and a Ca2+ and phospholipid-dependent association of the regulatory domain of protein kinase C with these sites. Expand
Kinetics and Redox-Sensitive Oligomerisation Reveal Negative Subunit Cooperativity in Tryparedoxin Peroxidase of Trypanosoma brucei brucei
The redox-dependent changes in shape and aggregation state, the kinetic pattern and molecular models support the view that, upon oxidation of a reaction center, other subunits adopt a conformation that has lower reactivity with the hydroperoxide. Expand
Identification of SRPK1 and SRPK2 as the Major Cellular Protein Kinases Phosphorylating Hepatitis B Virus Core Protein
It is concluded that both SRPK1 and SRPK2 are most likely the cellular protein kinases mediating HBV core protein phosphorylation during viral infection and therefore represent important host cell targets for therapeutic intervention in HBV infection. Expand
Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation
The data show that the age or gonadotropin‐dependent expression of PHGPx in testis does not result from direct transcriptional gene activation by testosterone, but is due to differentiation stage‐specific expression in late spermatids, which are under the control of Leydig cell‐derived testosterone. Expand
Tryparedoxin peroxidase of Leishmania donovani: molecular cloning, heterologous expression, specificity, and catalytic mechanism.
Site-directed mutagenesis confirmed that C52 and C173, as in related peroxiredoxins, are involved in catalysis, and the deduced mechanism may apply to most peroxIREDoxins and complements current views of peroxirescentoxin catalysis. Expand