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Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons
&NA; Nerve growth factor (NGF) regulates the nociceptive properties including sensitivity to capsaicin of a subset of dorsal root ganglion neurons, which express the high‐affinity NGF receptor, trkA.Expand
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The Proteinase-Activated Receptor 2 Is Involved in Nociception
The proteinase-activated receptor 2 is expressed on a subset of primary afferent neurons and may participate in the neurogenic component of inflammation. We hypothesized that this receptor may alsoExpand
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The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats.
BACKGROUND & AIMS Robust chemical or mechanical irritation of the colon of neonatal rats leads to chronic visceral hypersensitivity. The clinical and physiologic relevance of such noxious stimulationExpand
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Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis.
BACKGROUND & AIMS The neurobiologic basis of pancreatic hyperalgesia in chronic pancreatitis (CP) is understood poorly and there is a need to identify novel therapeutic targets. Our aim was to studyExpand
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Trypsin mediates nociception via the proteinase-activated receptor 2: a potentially novel role in pancreatic pain.
BACKGROUND & AIMS The pathogenesis of pain in pancreatitis remains poorly understood. We hypothesized that trypsin, a key inflammatory mediator in this condition, can also activate nociceptiveExpand
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P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity
Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterised by abdominal pain and bloating in association with altered bowel movements. Its pathogenesis and theExpand
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Enhanced excitability and suppression of A-type K+ current of pancreas-specific afferent neurons in a rat model of chronic pancreatitis.
Chronic pancreatitis (CP) is a relatively common disorder, characterized by glandular insufficiency and chronic, often intractable, pain. The mechanism of pain in CP is poorly understood. We haveExpand
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Adrenergic stimulation mediates visceral hypersensitivity to colorectal distension following heterotypic chronic stress.
BACKGROUND & AIMS Chronic stress exacerbates or causes relapse of symptoms such as abdominal pain and cramping in patients with irritable bowel syndrome. We investigated whether chronic stressExpand
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The endogenous hydrogen sulfide producing enzyme cystathionine-β synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome
BackgroundThe pathogenesis of visceral hypersensitivity, a characteristic pathophysiological feature of irritable bowel syndrome (IBS), remains elusive. Recent studies suggest a role for hydrogenExpand
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Differential immune and genetic responses in rat models of Crohn's colitis and ulcerative colitis.
Crohn's disease and ulcerative colitis are clinically, immunologically, and morphologically distinct forms of inflammatory bowel disease (IBD). However, smooth muscle function is impaired similarlyExpand
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