• Publications
  • Influence
Antioxidant defense of the brain: a role for astrocytes.
  • J. Wilson
  • Medicine
  • Canadian journal of physiology and pharmacology
  • 1997
TLDR
Following reactive gliosis, the neuroprotective role of astrocytes may be accentuated because of increases in a number of activities: expression of antioxidant enzymes; transport and metabolism of glucose that yields reducing equivalents for antioxidant regeneration and lactate for neuronal metabolism; synthesis of glutathione; and recycling of vitamin C. Expand
Glucose modulates vitamin C transport in adult human small intestinal brush border membrane vesicles.
TLDR
The results of this study suggest that DHAA crosses the apical membrane by facilitated diffusion, whereas ascorbate transport is a Na(+)-dependent, electrogenic process modulated by glucose. Expand
Asymmetry of sympathetic consequences of experimental stroke.
TLDR
Asymmetries of sympathetic regulation at the level of the inferior cervical ganglia have long been recognized, but this conclusion has remained tentative, since the differential effect of lateralized brain lesions on sympathetic activity has not been studied systematically. Expand
Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat.
TLDR
It is indicated that ascorbate is lost in the urine during sepsis and that a bolus of ascorBate can prevent microvascular dysfunction in the skeletal muscle of septic animals, which supports the view that asCorbate may be beneficial for patients with septic syndrome. Expand
Mechanisms of action of corticotropin-releasing factor and other regulators of corticotropin release in rat pituitary cells.
TLDR
The data demonstrate that the action of CRF on ACTH release is mediated by the adenylate cyclase-protein kinase pathway and that the sequence requirement for bioactivity includes the COOH-terminal 27 amino acid residues of the molecule. Expand
Effect of age on autonomic and cardiac responses in a rat stroke model.
TLDR
The results of this study are consistent with impaired sympathetic and cardiovascular regulation in the mature adult rat, and high sympathetic activity may represent one mechanism leading to fatal cardiac arrhythmias. Expand
Ascorbic Acid Uptake by a High‐Affinity Sodium‐Dependent Mechanism in Cultured Rat Astrocytes
  • J. Wilson
  • Biology, Medicine
  • Journal of neurochemistry
  • 1 October 1989
TLDR
It is concluded that astrocytes possess a stereoselective, high‐affinity, and Na+‐dependent uptake system for ascorbate, which may regulate the cerebral asCorbate concentration and consequently modulate neuronal function. Expand
Cerebral Astrocytes Transport Ascorbic Acid and Dehydroascorbic Acid Through Distinct Mechanisms Regulated by Cyclic AMP
TLDR
A role for cyclic AMP is indicated in accelerating the clearance and detoxification of DHAA in the brain anduptake and reduction ofDHAA by astrocytes may be a recycling pathway that contributes to brain AA homeostasis. Expand
The renin-angiotensin system in nonmammalian vertebrates.
  • J. Wilson
  • Biology, Medicine
  • Endocrine reviews
  • 1984
TLDR
Nonmammalian vertebrates are valuable models for studying the neurogenic actions of angiotensin II relevant to hypertensive disease, and modulation of sympathetic activity may be one of the most primitive and conservative functions of the RAS. Expand
Osmotic Swelling Stimulates Ascorbate Efflux from Cerebral Astrocytes
TLDR
Ascorbate release during astrocytic swelling may contribute to cellular osmoregulation in the short‐term and the scavenging of reactive oxygen species. Expand
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