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Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
To eat or to sleep? Orexin in the regulation of feeding and wakefulness.
- J. Willie, R. Chemelli, C. Sinton, M. Yanagisawa
- Biology, PsychologyAnnual review of neuroscience
These findings suggest that the orexin neuropeptide system plays a significant role in feeding and sleep-wakefulness regulation, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions.
Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice Molecular Genetic Dissection of Non-REM and REM Sleep Regulatory Processes
Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal
A role for the orexin system in molecular adaptations to morphine is supported, and dramatic differences in molecular responses among different populations of LH neurons are demonstrated.
Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity.
Orexin (Hypocretin) Neurons Contain Dynorphin
Findings suggest that dynorphin-A may play an important role in the function of the orexin neurons, which are common in the lateral hypothalamic area of mice and shown to influence feeding.
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice.
- Michihiro Mieda, J. Willie, J. Hara, C. Sinton, T. Sakurai, M. Yanagisawa
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 30 March 2004
Results indicate that orexin neuron-ablated mice retain the ability to respond to orexIn neuropeptides and that a temporally regulated and spatially targeted secretion of orexins is not necessary to prevent narcoleptic symptoms.
A consensus definition of cataplexy in mouse models of narcolepsy.
This working definition of murine cataplexy is an abrupt episode of nuchal atonia lasting at least 10 seconds that is common in mice with disrupted orexin/hypocretin signaling, but these events almost never occur in wild type mice.