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Transformation of artemisinin by Cunninghamella elegans
7β-hydroxyartemisinin, obtained from microbial transformation, is utilized as a semi-synthetic precursor for the synthesis of novel 7β-substituted art Artemisinin anti-malarial agents. Expand
Synthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives.
A novel series of heterocyclic o/m/p substituted diphenyl ether derivatives appear to have a novel mechanism of action against M. tuberculosis, and their structural features should be studied further for their potential use as new antitubercular drugs. Expand
Biocatalysis of the Antimalarial Artemisinin by Mucor ramannianus. Strains
Abstract Biocatalysis of artemisinin by different strains of Mucor ramannianus.* illustrates a simple approach to bioengineering for attaining useful biotransformation strains for preparative orExpand
Angiogenesis: new targets for the development of anticancer chemotherapies.
Angiogenesis is the process by which new blood vessels are formed from preexisting microvasculature. To ensure an adequate blood supply, tumor cells release angiogenic factors that are capable ofExpand
A review of cancer chemopreventive agents.
In the late 20(th) century, the treatment of cancer began to include its prevention. Today, compounds exist that will lower the risk of developing certain types of cancer. This has been demonstratedExpand
Helicobacter pylori: current chemotherapy and new targets for drug design.
  • J. Williamson
  • Biology, Medicine
  • Current pharmaceutical design
  • 28 February 2001
Helicobacter pylori infection is a major cause of many diseases of the gastrointestinal tract, including gastritis, non-ulcer dyspepsia, peptic ulcer disease, and gastric cancers. It is estimatedExpand
Ultra-performance liquid chromatography-tandem mass spectrometric method for the determination of Artemisinin in rat serum and its application in pharmacokinetics.
A rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated to quantify artemisinin in rat serum and can be separated from endogenous interferences inRat serum. Expand
Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger
Transformation of the anti-malarial drug artemisinin by the fungi Eurotium amstelodami and Aspergillus niger were investigated and metabolites from each fungal extract were isolated and identified using mass spectrometry and nuclear magnetic resonance. Expand
Hydroxylation of 10-deoxoartemisinin by Cunninghamella elegans.
The metabolites 2 and 4 retained an intact peroxide group and are therefore useful scaffolds for synthetic modification in the search for new antimalarial agents. Expand
Biotransformation of 10-deoxoartemisinin to its 7β-hydroxy derivative by Mucor ramannianus
The yield of product was increased from 16% to 45% by selecting optimal culture conditions using a 25−2 factorial design. Expand