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Carbonyl assays for determination of oxidatively modified proteins.
New methods for determination ofcarbonyl content are presented, which are based on the reaction of carbonyl groups with 2,4-dinitrophenylhydrazine to form a 2, 4-d Initrophenolhydrazone, which provide substantial improvements in both sensitivity and specificity. Expand
Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions.
To understand how the insect imaginal wing field is patterned, the temporal and spatial expression patterns of, and epistatic relationships between, four key regulatory genes that are specifically required for wing formation in Drosophila are examined. Expand
Cell turnover in neuromasts of zebrafish larvae
It is proposed that the dying population of cells are hair cells and the proliferating cells are 'mantle' supporting cells, which is in agreement with previous observations suggesting that supporting cells can give rise to hair cells following hair cell death. Expand
U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells.
The inability of U73122 to inhibit JMV-180-induced oscillations indicates that PI metabolism may not necessarily be a prerequisite for the generation of [Ca2+]i oscillations. Expand
Control of Drosophila wing and haltere development by the nuclear vestigial gene product.
It is shown that vg expression is spatially restricted to the presumptive wing and haltere regions of these imaginal discs of Dipteran flight appendages, suggesting that vG is directly involved in determining which thoracic imaginal disc cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. Expand
Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction.
- R. Liddle, I. Goldfine, M. Rosen, R. Taplitz, J. Williams
- Medicine, Chemistry
- The Journal of clinical investigation
- 1 April 1985
CCK can be bioassayed in fasting and postprandial human plasma and the studies suggest that CCK may be an important regulator of gallbladder contraction. Expand
Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2.
- R. Hinson, J. Williams, E. Shacter
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 14 May 1996
The results show that PGE2 can induce IL-6 production in vivo and implicate expression of the Cox-2 gene in the regulation of this cytokine. Expand
Stimulus-secretion coupling in pancreatic acinar cells.
The steps by which Ca2+ and cyclic AMP-mediated secretagogues activate enzyme secretion in the pancreatic acinar cell are summarized. Expand
Intracellular signaling mechanisms activated by cholecystokinin-regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells.
- J. Williams
- Biology, Medicine
- Annual review of physiology
The intracellular signaling mechanisms by which cholecystokinin (CCK) and other secretagogues regulate pancreatic acinar function are more complex than originally realized. CCK couples through… Expand
Molecular components of the circadian system in Drosophila.
It has, however, become clear that in addition to the brain clock, autonomous or semi-autonomous clocks occur in peripheral tissues where they confer circadian regulation on specific functions. Expand