Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
A selective and efficacious dual FAAH/MAGL inhibitor is described and it is shown that this agent exhibits broad activity in the tetrad test for CB1 agonism, causing analgesia, hypomotilty, and catalepsy, indicating that AEA and 2-AG signaling pathways interact to regulate specific behavioral processes in vivo, including those relevant to drug abuse.
Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia
3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor.
Effects of synthetic cathinones contained in "bath salts" on motor behavior and a functional observational battery in mice.
Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV)
The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific
- F. Niyuhire, S. Varvel, A. Thorpe, Rene J. Stokes, J. Wiley, A. Lichtman
- Psychology, BiologyPsychopharmacology
- 9 January 2007
The hypothesis that the CB1 receptor plays a vital role in the extinction of aversive memories but is not essential for extinction of learned responses in appetitively motivated tasks is supported.
Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects.
Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
- J. Wiley, D. R. Compton, B. Martin
- Chemistry, BiologyJournal of Pharmacology and Experimental…
- 1 June 1998
A series of indole- and pyrrole-derived cannabinoids was developed, in which the morpholinoethyl group was replaced with another cyclic structure or with a carbon chain that more directly corresponded to the side chain of Delta9-THC and were tested for CB1 binding affinity and in a battery of in vivo tests.
Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2)…
Antagonism of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rats and rhesus monkeys.
- J. Wiley, J. Lowe, R. Balster, B. Martin
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 October 1995
The present results suggest that SR141716A blocks the discriminative stimulus effects of delta 9-THC via a receptor-mediated mechanism and is predicted to block or reverse cannabis intoxication in humans.