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Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia
TLDR
Perinatal administration of phencyclidine results in long-term behavioral changes that may be mechanistically related to the apoptotic neurodegeneration observed in the frontal cortex, and it is postulated that these deficits may model the hypofrontality observed in schizophrenia. Expand
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
TLDR
A selective and efficacious dual FAAH/MAGL inhibitor is described and it is shown that this agent exhibits broad activity in the tetrad test for CB1 agonism, causing analgesia, hypomotilty, and catalepsy, indicating that AEA and 2-AG signaling pathways interact to regulate specific behavioral processes in vivo, including those relevant to drug abuse. Expand
3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor.
TLDR
The synthesis and pharmacology of 15 1-deoxy-delta8-THC analogues, several of which have high affinity for the CB2 receptor are described, and the affinities of each compound for theCB1 and CB2 receptors were determined employing previously described procedures. Expand
The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific
TLDR
The hypothesis that the CB1 receptor plays a vital role in the extinction of aversive memories but is not essential for extinction of learned responses in appetitively motivated tasks is supported. Expand
Effects of synthetic cathinones contained in "bath salts" on motor behavior and a functional observational battery in mice.
TLDR
Results suggest that individual synthetic cathinones differ in their profile of effects, and differ from known stimulants of abuse, suggesting that they may be just as harmful as the ones that have been banned. Expand
Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
TLDR
A series of indole- and pyrrole-derived cannabinoids was developed, in which the morpholinoethyl group was replaced with another cyclic structure or with a carbon chain that more directly corresponded to the side chain of Delta9-THC and were tested for CB1 binding affinity and in a battery of in vivo tests. Expand
Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2)
TLDR
Three new highly selective CB(2) receptor agonists were identified and docking studies indicated that the CB(1) receptor affinities of these compounds were consistent with their aromatic stacking interactions in the aromatic microdomain of theCB( 1) receptor. Expand
Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects.
TLDR
A role for the cannabinoid CB1 receptor in modulating seizure activity in a whole animal model is established and it is established that the anticonvulsant effects of delta9-tetrahydrocannabinol and WIN 55,212-2 are cannabinoid CB 1 receptor-mediated while the anticoagulant activity of cannabidiol is not. Expand
Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV)
TLDR
Findings represent the first evidence that second generation analogs of MDPV are catecholamine-selective uptake blockers which may pose risk for addiction and adverse effects in human users. Expand
Interactions between THC and cannabidiol in mouse models of cannabinoid activity
TLDR
As the amount of CBD found in most marijuana strains in the US is considerably less than that of THC, these results suggest that CBD concentrations relevant to what is normally found in marijuana exert very little, if any, modulatory effects on CB1-receptor-mediated pharmacological effects of marijuana smoke. Expand
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