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TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections.
AIMS Transforming growth factor-β (TGF-β) signaling is critical for the differentiation of smooth muscle cells (SMCs) into quiescent cells expressing a full repertoire of contractile proteins.Expand
Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies.
Cysteinyl S-nitrosylation has emerged as an important post-translational modification affecting protein function in health and disease. Great emphasis has been placed on global, unbiasedExpand
The cancer drug tamoxifen: a potential therapeutic treatment for spinal cord injury.
Tamoxifen (TMX) is a selective estrogen receptor modulator that can mimic the neuroprotective effects of estrogen but lacks its systemic adverse effects. We found that TMX (1 mg/day) significantlyExpand
Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins
The global prevalence of severe Clostridium difficile infection highlights the profound clinical significance of clostridial glucosylating toxins. Virulence is dependent on the autoactivation of aExpand
Src activation by b-adrenoreceptors is a key switch for tumour metastasis
Guillermo N. Armaiz-Pena1, Julie K. Allen1,2, Anthony Cruz3, Rebecca L. Stone1, Alpa M. Nick1, Yvonne G. Lin1, Liz Y. Han1, Lingegowda S. Mangala1,4, Gabriel J. Villares2,5, Pablo Vivas-Mejia6,7,Expand
Sildenafil Increases Muscle Protein Synthesis and Reduces Muscle Fatigue
Reductions in skeletal muscle function occur during the course of healthy aging as well as with bed rest or diverse diseases such as cancer, muscular dystrophy, and heart failure. However, there areExpand
Purification and properties of human kidney-cortex hexosaminidases A and B.
Hexosaminidases (EC A and B from human kidney cortex were purified to homogeneity by using concanavalin A affinity chromatography, ion-exchange chromatography and gel filtration. The yieldExpand
Interrelationship of hexosaminidases A and B: conformation of the common and the unique subunit theory.
Human kidney hexosaminidase A (beta-N-acetylglucosaminidase; 2-acetamido-2-deoxy-beta-D-glucoside acetamidodeoxyglucohydrolase; EC is a heteropolymer of two immunologically distinctExpand
Thiol‐reactive dyes for fluorescence labeling of proteomic samples
Covalent derivatization of proteins with fluorescent dyes prior to separation is increasingly used in proteomic research. This paper examines the properties of several commercially availableExpand
Characterization of polyethylene glycol modified proteins using charge-reversed capillary electrophoresis
Abstract A capillary electrophoretic method employing a charge reversal technique [J. E. Wiktorowicz and J. C. Colburn, Electrophoresis, 11 (1990) 769] has been developed to characterize polyethyleneExpand