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TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections.
Data support the conclusion that heterozygous TGFBR2 mutations lead to decreased expression of SMC contractile protein in both SMCs and myofibroblasts, and aligns with a hypothesis that defective SMCcontractile function contributes to the pathogenesis of TAAD.
Src activation by b-adrenoreceptors is a key switch for tumour metastasis
Guillermo N. Armaiz-Pena1, Julie K. Stone1, Alpa M. Gharpure1,2, Zheng Wu8,9, Robert D. English8, Kizhake V. Soman8, 9, Mian M. Shazhad1, Maya Zigler2,5, Michael T. Lutgendorf14,17 & Anil K. Sood1,4,5.
The cancer drug tamoxifen: a potential therapeutic treatment for spinal cord injury.
It is proposed that TMX is a promising candidate for the therapeutic treatment of SCI and a possible intervention for other neuropathological conditions associated with demyelination and AQP4 dysfunction.
Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies.
A novel quantitative approach that uses accurate, sensitive fluorescence modification of cysteine S-nitrosylation that leaves electrophoretic mobility unaffected (SNOFlo) and introduces unique concepts for measuring changes in S-Nitrosylated status relative to protein abundance is described.
Sildenafil Increases Muscle Protein Synthesis and Reduces Muscle Fatigue
- M. Sheffield-Moore, J. Wiktorowicz, W. Durham
- BiologyClinical and translational science
- 1 December 2013
It is shown that augmentation of nitric oxide‐cyclic guanosine monophosphate signaling by short‐term daily administration of the phosphodiesterase 5 inhibitor sildenafil increases protein synthesis, alters protein expression and nitrosylation, and reduces fatigue in human skeletal muscle.
Postsynaptic Proteome of Non-Demented Individuals with Alzheimer’s Disease Neuropathology
- O. Zolochevska, Nicole L. Bjorklund, R. Woltjer, J. Wiktorowicz, G. Taglialatela
- BiologyJournal of Alzheimer's disease : JAD
- 30 July 2018
A proteomic approach is used to compare the hippocampal postsynaptic densities of NDAN, AD, and healthy age-matched persons to identify protein signatures characteristic for these groups, thus setting them apart from control subjects and AD patients.
Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins
Allostery in bacterial proteins has thus been successfully exploited in the evolutionary development of nitrosothiol-based innate immunity and may provide an avenue to new therapeutic approaches.
Thiol‐reactive dyes for fluorescence labeling of proteomic samples
Covalent derivatization of proteins with fluorescent dyes prior to separation is increasingly used in proteomic research and is demonstrated to be compatible with in‐gel digestion and peptide mass fingerprinting by matrix assisted laser desorption/ionization‐mass spectrometry and allowed successful protein identification.
Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics
Together, inhibition of H2S-producing enzymes sensitize lung adenocarcinoma cells to chemotherapeutic agents via induction of mitochondrial dysfunction as shown in in vitro and in vivo models, suggesting a novel mechanism to overcome tumor chemoresistance.
Functional analysis of the nuclear proteome of human A549 alveolar epithelial cells by HPLC‐high resolution 2‐D gel electrophoresis
This database represents the most comprehensive data set of mammalian nuclear proteins and will serve as a foundation for further discovery.