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Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale
Efficacy of the Novel Anxiolytic Pregabalin in Social Anxiety Disorder: A Placebo-Controlled, Multicenter Study
- A. Pande, D. Feltner, J. Werth
- Psychology, MedicineJournal of clinical psychopharmacology
- 1 April 2004
Pregabalin 600 mg/d was an effective and well-tolerated treatment of social anxiety disorder and was not significantly better than placebo on any measures.
Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Gabapentin Bipolar Disorder Study Group.
- A. Pande, J. Crockatt, C. Janney, J. Werth, G. Tsaroucha
- Psychology, MedicineBipolar disorders
- 1 September 2000
The findings of this study did not demonstrate that gabapentin is an effective adjunctive treatment when administered to outpatients with bipolar disorder.
Modulation of calcium efflux from cultured rat dorsal root ganglion neurons
It is concluded that in DRG neurons PMCAs are responsible for lowering [Ca2+]i after small Ca2+ loads and that PMCA-mediated Ca 2+ efflux is modulated by calmodulin- and PKC- signaling pathways.
How Modeling and Simulation Have Enhanced Decision Making in New Drug Development
- Raymond Miller, W. Ewy, R. Lalonde
- Medicine, BiologyJournal of Pharmacokinetics and Pharmacodynamics
- 7 November 2005
The idea of model-based drug development championed by Lewis Sheiner, in which pharmacostatistical models of drug efficacy and safety are developed from preclinical and available clinical data,…
Nonrestorative sleep as a distinct component of insomnia.
Daytime symptoms were as severe in individuals with NRS-only as those whose NRS symptoms were combined with DIS or DMS and this study confirms that NRS can occur independently of other components of insomnia.
A method for determining the magnitude of change across different cognitive functions in clinical trials: the effects of acute administration of two different doses alprazolam
- P. Snyder, J. Werth, B. Giordani, A. Caveney, D. Feltner, P. Maruff
- PsychologyHuman psychopharmacology
- 1 June 2005
The results suggest that low‐dose alprazolam primarily alters visual attentional function and at the higher dose psychomotor functions also become impaired, and a method for directly comparing the magnitude of change in cognitive function between measures with different performance metrics is illustrated.
Reversible Physiological Alterations in Sympathetic Neurons Deprived of NGF but Protected from Apoptosis by Caspase Inhibition or Bax Deletion
- J. Werth, M. Deshmukh, Jeannette Cocabo, Eugene M. Johnson, S. Rothman
- BiologyExperimental Neurology
- 31 January 2000
Neurons are physiologically altered during pharmacological inhibition of PCD, but fully recover after trophic support is returned, indicating that inhibition of apoptosis is an attractive strategy for the therapy of many neurological diseases.
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam
- P. Maruff, J. Werth, B. Giordani, A. Caveney, D. Feltner, P. Snyder
- Psychology, MedicinePsychopharmacology
- 28 March 2006
The proposed method and analysis showed an excellent sensitivity and specificity for alprazolam-related cognitive deterioration in individuals, suggesting that statistically reliable decisions about the effects of sedative drugs on cognition can be made for individuals.
Mitochondrial Morphology and Intracellular Calcium Homeostasis in Cytochrome Oxidase-Deficient Human Fibroblasts
Results indicate that cytochrome oxidase deficiency, at the level in these cultures, does not produce structural or ionic concentration alterations in fibroblasts, and future investigation of the pathophysiology of this respiratory chain disorder may require excitable tissue.