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Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale
&NA; Pain intensity is frequently measured on an 11‐point pain intensity numerical rating scale (PI‐NRS), where 0=no pain and 10=worst possible pain. However, it is difficult to interpret theExpand
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Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons
  • J. Werth, S. Thayer
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 1 January 1994
We sought to determine whether low-affinity, high-capacity mitochondrial Ca2+ uptake contributes to buffering physiological Ca2+ loads in sensory neurons. Intracellular free calcium concentrationExpand
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Efficacy of the Novel Anxiolytic Pregabalin in Social Anxiety Disorder: A Placebo-Controlled, Multicenter Study
Abstract: Pregabalin is a novel compound in the development for the treatment of anxiety disorders. The safety and efficacy of pregabalin for the treatment of social anxiety disorder was evaluated inExpand
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Modulation of calcium efflux from cultured rat dorsal root ganglion neurons
The free intracellular Ca2+ concentration ([Ca2+]i) is governed by the balance between the activation of Ca2+ channels and buffering and efflux processes. We tested the hypothesis that Ca2+ effluxExpand
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Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Gabapentin Bipolar Disorder Study Group.
OBJECTIVES [corrected] To assess efficacy and safety of gabapentin in the treatment of bipolar disorder. METHODS This was a double-blind, placebo-controlled trial of adjunctive gabapentin (dosedExpand
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How Modeling and Simulation Have Enhanced Decision Making in New Drug Development
The idea of model-based drug development championed by Lewis Sheiner, in which pharmacostatistical models of drug efficacy and safety are developed from preclinical and available clinical data,Expand
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Nonrestorative sleep as a distinct component of insomnia.
STUDY OBJECTIVES Explore characteristics of nonrestorative sleep (NRS) in prospectively defined subgroups of individuals with NRS symptoms, investigate whether NRS can occur independently ofExpand
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A method for determining the magnitude of change across different cognitive functions in clinical trials: the effects of acute administration of two different doses alprazolam
While there is no doubt that benzodiazepine administration leads to transient cognitive impairment in healthy adults, the nature and magnitude of such impairment has not been well described. TheExpand
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Reversible Physiological Alterations in Sympathetic Neurons Deprived of NGF but Protected from Apoptosis by Caspase Inhibition or Bax Deletion
Cell death in nervous system development and in many neurodegenerative diseases appears to be apoptotic or programmed. Withdrawal of nerve growth factor (NGF) from cultures of superior cervicalExpand
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A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam
IntroductionThe effects of any drug treatment on cognitive function are typically studied in groups of subjects. Observations made about the behavior of the drug, in the study sample, are thenExpand
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