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Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale
View on Elsevier
Efficacy of the Novel Anxiolytic Pregabalin in Social Anxiety Disorder: A Placebo-Controlled, Multicenter Study
TLDR
Pregabalin 600 mg/d was an effective and well-tolerated treatment of social anxiety disorder and was not significantly better than placebo on any measures.
View on Wolters Kluwer
Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Gabapentin Bipolar Disorder Study Group.
TLDR
The findings of this study did not demonstrate that gabapentin is an effective adjunctive treatment when administered to outpatients with bipolar disorder.
View on PubMed
Modulation of calcium efflux from cultured rat dorsal root ganglion neurons
TLDR
It is concluded that in DRG neurons PMCAs are responsible for lowering [Ca2+]i after small Ca2+ loads and that PMCA-mediated Ca 2+ efflux is modulated by calmodulin- and PKC- signaling pathways.
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How Modeling and Simulation Have Enhanced Decision Making in New Drug Development
The idea of model-based drug development championed by Lewis Sheiner, in which pharmacostatistical models of drug efficacy and safety are developed from preclinical and available clinical data,…
View on Springer
Nonrestorative sleep as a distinct component of insomnia.
TLDR
Daytime symptoms were as severe in individuals with NRS-only as those whose NRS symptoms were combined with DIS or DMS and this study confirms that NRS can occur independently of other components of insomnia.
View on PubMed
A method for determining the magnitude of change across different cognitive functions in clinical trials: the effects of acute administration of two different doses alprazolam
TLDR
The results suggest that low‐dose alprazolam primarily alters visual attentional function and at the higher dose psychomotor functions also become impaired, and a method for directly comparing the magnitude of change in cognitive function between measures with different performance metrics is illustrated.
View on Wiley
Reversible Physiological Alterations in Sympathetic Neurons Deprived of NGF but Protected from Apoptosis by Caspase Inhibition or Bax Deletion
TLDR
Neurons are physiologically altered during pharmacological inhibition of PCD, but fully recover after trophic support is returned, indicating that inhibition of apoptosis is an attractive strategy for the therapy of many neurological diseases.
View on Elsevier
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam
TLDR
The proposed method and analysis showed an excellent sensitivity and specificity for alprazolam-related cognitive deterioration in individuals, suggesting that statistically reliable decisions about the effects of sedative drugs on cognition can be made for individuals.
View on Springer
Mitochondrial Morphology and Intracellular Calcium Homeostasis in Cytochrome Oxidase-Deficient Human Fibroblasts
TLDR
Results indicate that cytochrome oxidase deficiency, at the level in these cultures, does not produce structural or ionic concentration alterations in fibroblasts, and future investigation of the pathophysiology of this respiratory chain disorder may require excitable tissue.
View on Elsevier
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