• Publications
  • Influence
Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis.
BACKGROUND & AIMS Patients with cirrhosis hospitalized for an acute decompensation (AD) and organ failure are at risk for imminent death and considered to have acute-on-chronic liver failure (ACLF).Expand
  • 1,312
  • 114
Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
BACKGROUND Although the King's College Hospital (KCH) selection criteria for emergency liver transplantation in paracetamol-induced acute liver failure are widely used, strategies to improveExpand
  • 414
  • 24
  • PDF
Acute liver failure.
Worldwide, viral infection is responsible for the majority of cases of acute liver failure, and the presence of co-existing chronic viral hepatitis may increase its severity. The newly describedExpand
  • 275
  • 22
Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013.
Bacterial infections are very common and represent one of the most important reasons of progression of liver failure, development of liver-related complications, and mortality in patients withExpand
  • 515
  • 21
  • PDF
The importance of immune dysfunction in determining outcome in acute liver failure.
Acute liver failure (ALF) shares striking similarities with septic shock with regard to the features of systemic inflammation, progression to multiple organ dysfunction and functional immunoparesis.Expand
  • 232
  • 13
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.
OBJECTIVE--To see whether intravenous acetylcysteine would improve outcome in patients with fulminant hepatic failure after paracetamol overdose. DESIGN--A prospective randomised controlled study.Expand
  • 393
  • 12
  • PDF
Pilot‐controlled trial of the extracorporeal liver assist device in acute liver failure
The objective of this pilot controlled study was to evaluate the extracorporeal liver assist device (ELAD) in patients with acute liver failure who were judged to still have a significant chance ofExpand
  • 498
  • 12
Intensive care of the patient with cirrhosis
Acute deterioration of patients with cirrhosis manifests as multiple organ failure requiring admission to an intensive care unit. Precipitating events may be viral hepatitis, typically in Asia, andExpand
  • 193
  • 12
Circulatory, respiratory, cerebral, and renal derangements in acute liver failure: pathophysiology and management.
Many of the hemodynamic abnormalities seen in acute liver failure (ALF) have now been characterized. A lowered systemic vascular resistance with a raised cardiac output are prominent features, whichExpand
  • 150
  • 12
Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure
High circulating ammonia concentrations are common in patients with acute liver failure (ALF) and are associated with hepatic encephalopathy (HE) and intracranial hypertension (ICH). Other riskExpand
  • 330
  • 11
  • PDF