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Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis.
Diagnostic criteria for ACLF was established and showed that it is distinct from AD, based not only on the presence of organ failure(s) and high mortality rate but also on age, precipitating events, and systemic inflammation.
Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations
These definitions, guidelines, and recommendations, based upon current best evidence and expert opinion are proposed to assist clinicians in the management of IAH and ACS as well as serve as a reference for future clinical and basic science research.
Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions
State-of-the-art definitions for IAH and ACS are proposed based upon current medical evidence as well as expert opinion and recommended that these definitions be used for future clinical and basic science research.
Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
The systemic inflammatory response syndrome in acute liver failure
- N. Rolando, J. Wade, M. Dávalos, J. Wendon, J. Philpott‐Howard, Roger Williams
- 1 October 2000
In ALF, the SIRS, whether or not precipitated by infection, appears to be implicated in the progression of encephalopathy, reducing the chances of transplantation and conferring a poorer prognosis.
Acute liver failure.
Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013.
Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis
Assessment of ACLF patients at 3‐7 days of the syndrome provides a tool to define the emergency of LT and a rational basis for intensive care discontinuation owing to futility.
Intensive care of the patient with cirrhosis
Care of critically ill patients with impending multiple organ failure requires a team approach with expertise in both hepatology and critical care, aimed at preventing further deterioration in liver function, reversing precipitating factors, and supporting failing organs.