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A Novel Autotaxin Inhibitor Reduces Lysophosphatidic Acid Levels in Plasma and the Site of Inflammation
TLDR
The development of a potent autotaxin inhibitor PF-8380 is reported, which can serve as a tool compound for elucidating LPA's role in inflammation and suggests that LPA is rapidly formed and degraded in vivo. Expand
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
TLDR
PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of Sphk1-driven S1P signalling, indicating that the SphK 1 isoform of sphingosine kinase is the major source of S 1P in human blood. Expand
Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists.
TLDR
During TH17 differentiation, cholesterol biosynthesis and uptake programs are induced, whereas their metabolism and efflux programs are suppressed, which results in the accumulation of the cholesterol precursor, desmosterol, which functions as a potent endogenous RORγ agonist. Expand
Identification and Characterization of a Novel Δ6/Δ5 Fatty Acid Desaturase Inhibitor As a Potential Anti-Inflammatory Agent
TLDR
Results suggest that Δ5 and/or Δ6 desaturase inhibitors have the potential to manifest an anti-inflammatory response by decreasing the level of AA and the ensuing production of eicosanoids. Expand
Relative distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatic and adipose tissues.
TLDR
Paired human hepatic and adipose tissues from 26 people were assayed for 2,3,7,8-tetrachlorodibenzo-p-dioxin and TCDD appeared to be partitioning into the human liver predominantly on the basis of its lipid solubility in that tissue store. Expand
Chlorocarbons in adipose tissue from a Missouri population
Abstract Specimens of abdominal wall adipose tissue from 35 individuals who died in St. Louis, MO, were analyzed by an isomer-specific GC/MS technique for 2, 3, 7, 8-substituted tetra- throughExpand
Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent.
TLDR
Results suggest that delta5 and/or delta6 desaturase inhibitors have the potential to manifest an anti-inflammatory response by decreasing the level of AA and the ensuing production of eicosanoids. Expand
An analytical assessment of the bioavailability of dioxin contaminated soils to animals
Abstract Single-dose gavage studies of Times Beach, MO and Newark, NJ dioxin contaminated soils were done to determine relative bioavailability in guinea pigs. GC/MS analysis of the animals' liversExpand
Corrigendum: Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists.
TLDR
In the version of this article initially published, the zymosterol and zy mostenol structures shown in Figure 3a were depicted with a double bond at C14-C15, where there should have been a single bond. Expand
Methodology for the analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin in feces
Abstract A methodology for the analysis of 2378-TCDD in feces is presented. This method involves complete digestion of lyophilized feces, extraction and cleanup by routine column chromatography.Expand
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