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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
TLDR
It is found that a complex interplay of genetic events contributes to AML pathogenesis in individual patients and the databases from this study are widely available to serve as a foundation for further investigations of AMl pathogenesis, classification, and risk stratification. Expand
Clonal evolution in relapsed acute myeloid leukemia revealed by whole genome sequencing
TLDR
The sequenced primary tumour and relapse genomes from eight AML patients and validated hundreds of somatic mutations using deep sequencing demonstrated that AML relapse is associated with the addition of new mutations and clonal evolution, which is shaped by the chemotherapy that the patients receive to establish and maintain remissions. Expand
Mutational landscape and significance across 12 major cancer types
TLDR
Data and analytical results for point mutations and small insertions/deletions from 3,281 tumours across 12 tumour types are presented as part of the TCGA Pan-Cancer effort, and clinical association analysis identifies genes having a significant effect on survival. Expand
The Origin and Evolution of Mutations in Acute Myeloid Leukemia
TLDR
The data suggest that most of the mutations found in AML genomes are actually random events that occurred in HSPCs before they acquired the initiating mutation; the mutational history of that cell is "captured" as the clone expands. Expand
15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.
TLDR
It is reported here that 15d-PGJ(2) potently inhibits NF-kappaB-dependent transcription by two additional PPARgamma-independent mechanisms that act in combination to inhibit transactivation of the NF- kappaB target gene cyclooxygenase 2. Expand
Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
TLDR
Findings reveal a physiological role of 12/15-lipoxygenase in the generation of endogenous ligands for PPAR-γ, and suggest a paradigm for the regulation of nuclear receptor function by cytokines. Expand
Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase.
TLDR
Findings reveal a physiological role of 12/15-lipoxygenase in the generation of endogenous ligands for PPAR-gamma, and suggest a paradigm for the regulation of nuclear receptor function by cytokines. Expand
SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution
TLDR
SciClone is a computational method that is used to detect subclones in acute myeloid leukemia and breast cancer samples that, though present at disease onset, are not evident from a single primary tumor sample, and can track tumor evolution and identify the spatial origins of cells resisting therapy. Expand
Age-related cancer mutations associated with clonal hematopoietic expansion
TLDR
The analyses show that the blood cells of more than 2% of individuals contain mutations that may represent premalignant events that cause clonal hematopoietic expansion, and several recurrently mutated genes that may be disease initiators are identified. Expand
DNMT3A mutations in acute myeloid leukemia.
TLDR
DNMT3A mutations are highly recurrent in patients with de novo AML with an intermediate-risk cytogenetic profile and are independently associated with a poor outcome in Cox proportional-hazards analysis. Expand
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