Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin.
- J. Weiss, P. Andersson, M. Lamoree, P. Leonards, S. V. van Leeuwen, T. Hamers
- Biology, ChemistryToxicological Sciences
- 1 June 2009
Competitive binding of PFCs to TTR, as observed for human TTR in the present study, may explain altered thyroid hormone levels described for PFC-exposed rats and monkeys.
Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in The Netherlands.
- L. Meijer, J. Weiss, M. V. van Velzen, A. Brouwer, Å. Bergman, P. Sauer
- ChemistryEnvironmental Science and Technology
- 1 May 2008
It is concluded that OHCs are present in the serum of pregnant women, and all compounds tested are transferred over the placenta.
Masking effect of anti-androgens on androgenic activity in European river sediment unveiled by effect-directed analysis
- J. Weiss, T. Hamers, K. Thomas, S. C. van der Linden, P. Leonards, M. Lamoree
- BiologyAnalytical and Bioanalytical Chemistry
- 6 May 2009
This study shows that the androgen receptor agonistic potency is clearly concealed by the effects of androgen receptor antagonists in a total sediment extract, demonstrating that toxicity screening…
Contaminants of emerging concern in the Hartbeespoort Dam catchment and the uMngeni River estuary 2016 pollution incident, South Africa.
- Cornelius Rimayi, D. Odusanya, J. Weiss, J. de Boer, L. Chimuka
- Environmental ScienceScience of the Total Environment
- 1 June 2018
Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen's wives and associations with bone density.
- J. Weiss, E. Wallin, Å. Bergman
- ChemistryEnvironmental Science and Technology
- 9 September 2006
No associations were found between bone mineral density or biochemical markers of bone metabolism and the analyzed environmental pollutants, and the association between these pollutants and bone density was investigated.
PBDE and HBCDD levels in blood from Dutch mothers and infants - Analysis of a Dutch Groningen Infant Cohort
- J. Weiss, L. Meijer, P. Sauer, L. Linderholm, I. Athanassiadis, Å. Bergman
- Medicine
- 2004
Concentrations of dioxins and other organochlorines (PCBs, DDTs, HCHs) in human milk from Seveso, Milan and a Lombardian rural area in Italy: a study performed 25 years after the heavy dioxin…
- J. Weiss, O. Päpke, R. Zetterström
- ChemistryActa paediatrica
- 1 April 2003
The TCDD concentration in fat calculated on a fresh weight basis was more than twice as high as the level in the other two regions, whereas the concentrations of investigated other toxins were lower in Seveso possible due to induction of the enzyme cytochrome P4501A, which means that the total level of dioxins was the same in all three locations.
Cats' Internal Exposure to Selected Brominated Flame Retardants and Organochlorines Correlated to House Dust and Cat Food.
- J. Norrgran Engdahl, A. Bignert, B. Jones, I. Athanassiadis, Å. Bergman, J. Weiss
- ChemistryEnvironmental Science and Technology
- 21 February 2017
This is the first time a correlation between cat serum levels and household dust has been established, a finding that supports the hypothesis that dust is a significant exposure route for cats.
Polar compounds dominate in vitro effects of sediment extracts.
- Urte Lübcke-von Varel, M. Machala, W. Brack
- ChemistryEnvironmental Science and Technology
- 24 February 2011
Not only nonpolar compounds such as PAHs, PCBs, and PCDD/Fs but also the less characterized and investigated more polar substances should be considered as potent mutagenic, estrogenic, AhR-inducing, TTR-binding, and GJIC-inhibiting components for future studies.
In Silico Approach To Identify Potential Thyroid Hormone Disruptors among Currently Known Dust Contaminants and Their Metabolites.
- Jin Zhang, J. Kamstra, Mehdi Ghorbanzadeh, J. Weiss, T. Hamers, P. Andersson
- Biology, ChemistryEnvironmental Science and Technology
- 6 August 2015
Four new THDCs were identified using an in silico approach in combination with bioassay testing and the importance of metabolic activation for TTR binding was highlighted; 2,2',4,4'-tetrahydroxybenzophenone, perfluoroheptanesulfonic acid, 3,5,6- trichloro-2-pyridinol, and 2,4,5-trichlorophenoxyacetic acid.
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