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Whole-cell recording of the Ca2+-dependent slow afterhyperpolarization in hippocampal neurones: effects of internally applied anions
It is suggested that among anions commonly used in electrode filling solutions for whole-cell recordings, methylsulfate is the least disruptive to intracellular structures or Ca2+ homeostasis and permits stable whole- cell recording of the IAHP and Ca2-activated currents in mammalian CNS neurones. Expand
Potentiation of GABAA-mediated synaptic current by ethanol in hippocampal CA1 neurons: possible role of protein kinase C.
It is demonstrated that ethanol potentiation of pharmacologically isolated GABAA IPSCs can be modulated by protein kinase C, and the active phorbol ester 4-beta-PDBu but not its inactive analog also interferes with ethanol enhancement of GAB AA IPSCs. Expand
Guanosine phosphate analogs modulate ethanol potentiation of GABAA-mediated synaptic currents in hippocampal CA1 neurons
The results suggest that one or more G-protein coupled events regulate the ethanol sensitivity of synaptic GABAA receptors. Expand
Potentiation of gamma-aminobutyric acid type A receptor-mediated synaptic currents by pentobarbital and diazepam in immature hippocampal CA1 neurons.
It is suggested that functional GABAA/benzodiazepine receptors are expressed in neonatal CA1 hippocampal neurons, however, their sensitivity to benzodiazepines is altered by intracellular ATP. Expand
Muscarinic potentiation of IK in hippocampal neurons: electrophysiological characterization of the signal transduction pathway
It is reported that activation of muscarinic receptors potentiates a voltage- activated, sustained K+ current (IK-type), mediated by activation of protein kinase C and involves a G-protein- linked, intracellular Ca(2+)-dependent process. Expand
The role of calcium homeostasis and calcium currents in ethanol actions on central mammalian neurons.
The ubiquitous role of calcium in ethanol actions measured electrophysiologically in central neurons is discussed and Ca2+ is implicated in all of the above ethanol mediated effects. Expand