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A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer
- J. Amos-Landgraf, Lawrence N. Kwong, +8 authors W. Dove
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 6 March 2007
Progress toward the understanding and management of human colon cancer can be significantly advanced if appropriate experimental platforms become available. We have investigated whether a rat model… Expand
Fluorescent cancer-selective alkylphosphocholine analogs for intraoperative glioma detection.
BACKGROUND 5-Aminolevulinic acid (5-ALA)-induced tumor fluorescence aids brain tumor resections but is not approved for routine use in the United States. We developed and describe testing of 2 novel… Expand
Beyond the margins: real-time detection of cancer using targeted fluorophores
- R. Zhang, A. B. Schroeder, +6 authors J. Weichert
- Nature Reviews Clinical Oncology
- 17 January 2017
Over the past two decades, synergistic innovations in imaging technology have resulted in a revolution in which a range of biomedical applications are now benefiting from fluorescence imaging.… Expand
Imaging of murine liver tumor using microCT with a hepatocyte-selective contrast agent: accuracy is dependent on adequate contrast enhancement.
INTRODUCTION A major limitation in using both spontaneous and implanted murine liver tumor models in cancer research is the inability to accurately detect and monitor tumor volume. Because microCT… Expand
Lipid-based blood-pool CT imaging of the liver.
RATIONALE AND OBJECTIVES We have recently developed an iodinated lipid-based contrast agent capable of residing in the blood pool for extended periods of time relative to conventional water-soluble… Expand
Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma.
- B. Hafeez, W. Zhong, J. Weichert, N. Dreckschmidt, M. S. Jamal, A. Verma
- Biology, Medicine
- Cancer research
- 15 March 2011
Protein kinase C epsilon (PKCε), a novel PKC isoform, is overexpressed in prostate cancer (PCa) and correlates with disease aggressiveness. However, the functional contribution of PKCε to development… Expand
Combined hepatocyte-selective and blood-pool contrast agents for the CT detection of experimental liver tumors in rabbits.
PURPOSE To determine the imaging characteristics of a new computed tomographic (CT) contrast material with both hepatocyte-selective and blood-pool components (iodinated triglyceride (ITG)-dual)… Expand
PIK3CA and APC mutations are synergistic in the development of intestinal cancers
Human colorectal cancers are known to possess multiple mutations, though how these mutations interact in tumor development and progression has not been fully investigated. We have previously… Expand
Hybrid PET/CT for noninvasive pharmacokinetic evaluation of dynamic PolyConjugates, a synthetic siRNA delivery system.
- Sarah R. Mudd, V. Trubetskoy, A. Blokhin, J. Weichert, J. Wolff
- Chemistry, Medicine
- Bioconjugate chemistry
- 16 June 2010
Positron emission tomography/computed tomography (PET/CT) hybrid imaging can be used to gain insights into a synthetic siRNA delivery system targeted to the liver. Either siRNA or the delivery… Expand
Alkylphosphocholine Analogs for Broad-Spectrum Cancer Imaging and Therapy
Tumor-specific alkylphosphocholine analogs were evaluated as imaging and therapy agents in patients and in animal models of human cancer. A Broad View of Cancer Many consider targeted or molecular… Expand