Bioprocessing of plant cell cultures for mass production of targeted compounds
- Milen I Georgiev, J. Weber, A. Maciuk
- Biology, EngineeringApplied Microbiology and Biotechnology
- 2 June 2009
Recent advances in bioprocessing aspects of plant cell cultures, from callus culture to product formation, are summarized, with particular emphasis on the development of suitable bioreactor configurations (e.g., disposable reactors) for plant cell culture-based processes.
Antioxidant Activity and Phenolic Content of Betalain Extracts from Intact Plants and Hairy Root Cultures of the Red Beetroot Beta vulgaris cv. Detroit Dark Red
- V. Georgiev, J. Weber, Eva-Maria Kneschke, P. Denev, T. Bley, A. Pavlov
- Chemistry, MedicinePlant foods for human nutrition
- 27 February 2010
The high antioxidant activity of the hairy root extracts was associated with increased concentrations (more than 20-fold) of total phenolic concomitant compounds, which may have synergistic effects with betalains.
Microbubble fermentation of Trichoderma reesei for cellulase production
- J. Weber, F. Agblevor
- Engineering
- 1 February 2005
Constitutive expression of hydrophobin HFB1 from Trichoderma reesei in Pichia pastoris and its pre‐purification by foam separation during cultivation
- Kirsten Kottmeier, Tobias J. Günther, T. Bley
- Biology, Engineering
- 1 April 2012
The presented data show that Pichia pastoris is a suitable system for production of constitutively expressed and secreted active hydrophobin, allowing for in situ pre‐purification using foam separation.
Exploring small-scale chemostats to scale up microbial processes: 3-hydroxypropionic acid production in S. cerevisiae
- Alicia V. Lis, Konstantin Schneider, J. Weber, J. Keasling, M. K. Jensen, Tobias Klein
- Biology, EngineeringMicrobial Cell Factories
- 11 March 2019
Small-scale chemostat cultures are well suited for the physiological characterization of microorganisms, particularly for investigating the effect of changing cultivation parameters on microbial performance and thus the small-scaleChemostat system as powerful tool for process optimization.
Growth and exopolysaccharide yield of Lactobacillus delbrueckii ssp. bulgaricus DSM 20081 in batch and continuous bioreactor experiments at constant pH.
- S. Mende, Leona Krzyzanowski, J. Weber, D. Jaros, H. Rohm
- Medicine, BiologyJournal of Bioscience and Bioengineering
- 1 February 2012
Green bioprinting: Fabrication of photosynthetic algae‐laden hydrogel scaffolds for biotechnological and medical applications
- A. Lode, F. Krujatz, M. Gelinsky
- Biology, Engineering
- 1 March 2015
Using 3D plotting, microalgae of the species Chlamydomonas reinhardtii were embedded in 3D alginate‐based scaffolds and were able to grow within the hydrogel matrix and establish a patterned coculture system in which the algae are cultivated in close vicinity to human cells.
Hydrogen production by Rhodobacter sphaeroides DSM 158 under intense irradiation.
- F. Krujatz, P. Härtel, J. Weber
- EngineeringBioresource Technology
- 2015
Bioreactors for plant cells: hardware configuration and internal environment optimization as tools for wider commercialization
- Milen I Georgiev, J. Weber
- Biology, EngineeringBiotechnology Letters
- 27 February 2014
This review highlights recent progress in hardware configuration and optimization of bioreactor culture conditions for suspended plant cells.
Bioactive metabolite production and stress-related hormones in Devil’s claw cell suspension cultures grown in bioreactors
- Milen I Georgiev, J. Ludwig-Müller, J. Weber, N. Stancheva, T. Bley
- Biology, EngineeringApplied Microbiology and Biotechnology
- 1 March 2011
The phenylethanoid biosynthetic process was transferred to a 3-L stirred tank reactor and a 1-L glass-column bioreactor (operated with pulsed aeration) and it was found that, with stepwise increases in aeration, the stirred tank reactors yielded similar productivities of verbascoside to those reported for shake-flask cultures.
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