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Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.
TLDR
The unique folding of this conserved Sir3 AAA(+) domain generates novel surface regions that mediate Sir3-Sir4 andSir3-nucleosome interactions, both being required for the proper assembly of heterochromatin in living cells. Expand
Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate
TLDR
The data suggest a mechanism for boundary formation whereby histone deacetylation by Rpd3 removes the substrate for the HDAC Sir2, so that Sir2 no longer can produce O-acetyl-ADP ribose (OAADPR) by consumption of NAD+ in the de acetylation reaction. Expand
Pheromones and Pheromone Receptors Are Required for Proper Sexual Development in the Homothallic Ascomycete Sordaria macrospora
TLDR
Pheromones and pheromone receptors are required for optimal sexual reproduction of the homothallic, filamentous ascomycete S. macrospora. Expand
Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase
TLDR
A role for histone deacetylation in origin activity is demonstrated and a novel aspect of origin regulation by chromatin is revealed, suggesting recruitment of the Sum1/Rfm1/Hst1 complex to a number of yeast origins, where Hst1deacetylated H4 K5. Expand
A role for CENP-A/Cse4 phosphorylation on serine 33 in deposition at the centromere
TLDR
The data highlight the importance of correct histone deposition in building a functional centromeric nucleosome and suggests a role for Cse4-S33ph in this process. Expand
Design of a minimal silencer for the silent mating-type locus HML of Saccharomyces cerevisiae
TLDR
A fully functional, minimal HML-E silencer that was sensitive to a mutation in RAP1, rap1-12, but less sensitive to orc mutations or sum1Δ, and useful to identify novel factors involved in HML silencing. Expand
The day and night activity pattern of the stoat (Mustela erminea L.)
TLDR
Une activite de deplacement accrue serait a l'origine du rythme plus diurne des juveniles par rapport aux adultes a la fin of l'ete et en automne. Expand
Quantitative aspects of the life cycle ofSkrjabingylus nasicola, a parasitic nematode of the frontal sinuses of mustelids
TLDR
A quantitative study of the life cycle of Skrjabingylus nasicola found that a significant number of L3 encapsulate in the anterior part of the paratenic host, which means that the cephalic glandular zones, salivary and lacrymal glands, and maybe the musculature and connective tissues ofApodemus sp. Expand
Genome-wide H4 K16 acetylation by SAS-I is deposited independently of transcription and histone exchange
TLDR
The data suggest that Sas2-dependent H4 K16Ac is deposited into chromatin independently of transcription and histone exchange, and that it has an inhibitory effect on the ability of PolII to travel through the body of the gene. Expand
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